Gene: USP2
Official Full Name: ubiquitin specific peptidase 2provided by HGNC
Gene Summary: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00296 | USP2 Knockout cell line (HeLa) | Human | USP2 | 1:3~1:6 | Negative | Online Inquiry |
KO00540 | USP2 Knockout cell line (HEK293) | Human | USP2 | 1:3~1:6 | Negative | Online Inquiry |
KO09459 | USP2 Knockout cell line (HCT 116) | Human | USP2 | 1:2~1:4 | Negative | Online Inquiry |
KO09460 | USP2 Knockout cell line (A549) | Human | USP2 | 1:3~1:4 | Negative | Online Inquiry |
USP2 Gene Knockout Cell Lines are engineered cell models specifically designed to facilitate the study of the ubiquitin-specific peptidase 2 (USP2) gene's role in various biological processes. By employing advanced gene-editing technologies, such as CRISPR-Cas9, these cell lines enable researchers to effectively knock out the USP2 gene, allowing for a functional analysis of its contribution to cellular homeostasis, protein degradation pathways, and the regulation of cell signaling.
The primary mechanism of action involves the disruption of USP2 expression, leading to the modulation of ubiquitination processes that are crucial for controlling protein stability and turnover. This knockout model provides a unique platform for investigating the implications of USP2 in cancer biology, neurodegenerative diseases, and metabolic disorders. It allows researchers to observe the phenotypic outcomes of USP2 depletion, which could uncover therapeutic targets for intervention in various pathologies.
Scientifically, USP2 Gene Knockout Cell Lines are invaluable in both research and clinical settings. They contribute to a deeper understanding of protein homeostasis and its dysregulation in diseases, thus paving the way for novel therapeutic approaches. Moreover, these cell lines offer a reliable and reproducible means to study therapeutic compounds that target USP2, making them a critical resource for drug development.
One notable advantage of our USP2 Gene Knockout Cell Lines is their high specificity and consistency as compared to alternative methods like RNA interference. This specificity reduces off-target effects and ensures more reliable data interpretation, which is essential for rigorous scientific inquiry.
For researchers and clinicians focused on uncovering the multifaceted roles of ubiquitin-specific peptidases, USP2 Gene Knockout Cell Lines represent a cutting-edge tool that enhances experimental precision. With our commitment to quality and innovation, our company brings years of expertise in providing life science tools that empower the scientific community to make significant advancements in their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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