Gene: ULK2
Official Full Name: unc-51 like autophagy activating kinase 2provided by HGNC
Gene Summary: This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00088 | ULK2 Knockout cell line (U-2 OS) | Human | ULK2 | 1:3~1:5 | Negative | Online Inquiry |
KO00178 | ULK2 Knockout cell line (HCT 116) | Human | ULK2 | 1:2~1:4 | Negative | Online Inquiry |
KO00179 | ULK2 Knockout cell line (A549) | Human | ULK2 | 1:3~1:4 | Negative | Online Inquiry |
KO09139 | ULK2 Knockout cell line (HeLa) | Human | ULK2 | 1:3~1:6 | Negative | Online Inquiry |
KO09140 | ULK2 Knockout cell line (HEK293) | Human | ULK2 | 1:3~1:6 | Negative | Online Inquiry |
ULK2 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the function of the Unc-51 Like Autophagy Activating Kinase 2 (ULK2) within the context of autophagy and cellular homeostasis. These cell lines are created by employing CRISPR/Cas9 genome editing technology, enabling targeted knockout of the ULK2 gene, thus allowing researchers to investigate the downstream effects of ULK2’s absence on various cellular pathways, including stress responses and metabolic regulation.
The primary function of these knockout cell lines lies in their ability to elucidate the role of ULK2 in autophagy initiation, a critical cellular process responsible for degrading dysfunctional proteins and organelles. By utilizing these cell lines, scientists can rigorously assess how ULK2 influences autophagy-related pathways, providing insights into diseases linked to dysregulated autophagy, such as neurodegenerative disorders, cancer, and metabolic syndromes.
From a scientific perspective, ULK2 knockout cell lines serve as invaluable tools in both basic and applied research settings. They enable the identification of potential therapeutic targets and the evaluation of drug efficacy in modulating autophagy-related processes. Furthermore, compared to other gene knockout models, our ULK2 cell lines offer superior stability and reproducibility, engineered for optimal expression profiles that are closely aligned with physiological conditions.
What sets our ULK2 Gene Knockout Cell Lines apart is their application-ready format and ease of use, making them accessible for various experimental purposes. Researchers and clinicians can quickly obtain relevant results without the cumbersome safeguarding often required with traditional knockout methodologies.
In summary, these cell lines represent a significant advancement in the toolbox of molecular biologists and clinical researchers dedicated to understanding cellular mechanisms. With our extensive expertise in genetic engineering and a commitment to delivering high-quality biological products, we are proud to support scientific innovation through our ULK2 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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