Gene: UIMC1
Official Full Name: ubiquitin interaction motif containing 1provided by HGNC
Gene Summary: This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09576 | UIMC1 Knockout cell line (HeLa) | Human | UIMC1 | 1:3~1:6 | Negative | Online Inquiry |
KO09577 | UIMC1 Knockout cell line (HCT 116) | Human | UIMC1 | 1:2~1:4 | Negative | Online Inquiry |
KO09578 | UIMC1 Knockout cell line (HEK293) | Human | UIMC1 | 1:3~1:6 | Negative | Online Inquiry |
KO09579 | UIMC1 Knockout cell line (A549) | Human | UIMC1 | 1:3~1:4 | Negative | Online Inquiry |
UIMC1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the UIMC1 gene, a critical component involved in DNA repair and cellular signaling processes. This knockout approach allows researchers to study the functional roles of UIMC1 in various biological contexts, providing insights into cellular mechanisms related to cancer, aging, and response to DNA damage. The UIMC1 gene is particularly relevant as it may contribute to tumorigenesis, making its study essential for understanding cancer biology.
The key mechanism of the UIMC1 Gene Knockout Cell Lines lies in their ability to elucidate the signaling pathways and biological processes influenced by the absence of functional UIMC1 protein. By utilizing these knockout cell lines, researchers can observe changes in cell proliferation, apoptosis, and DNA repair efficiency, thereby unveiling the role of UIMC1 in these critical cellular functions. These models are invaluable for screening compounds that may restore function or disrupt pathways influenced by UIMC1, which is crucial in developing targeted therapies.
In the realm of scientific research, UIMC1 Gene Knockout Cell Lines offer significant advantages over traditional models. Unlike knockdown approaches that may produce residual gene activity, knockout lines ensure a complete absence of the target gene, providing clearer, more interpretable experimental results. Furthermore, their application spans diverse fields, from cancer research to genetic studies, thus appealing to a wide audience of scientists and clinicians alike.
For researchers and clinicians seeking to deepen their understanding of cellular mechanisms or to identify novel therapeutic strategies, UIMC1 Gene Knockout Cell Lines provide an unmatched resource. The ability to manipulate and observe the effects of a gene knockout allows for precise experimental designs and robust data collection, fostering advancements in molecular biology and medicine.
With a robust background in genomic technologies and a commitment to delivering high-quality biological products, our company specializes in providing innovative research tools like UIMC1 Gene Knockout Cell Lines, empowering the scientific community to explore complex biological questions with precision and reliability.
Please note that all services are for research use only. Not intended for any clinical use.
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