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UFL1 Knockout Cell Lines

Gene: UFL1

Official Full Name: UFM1 specific ligase 1provided by HGNC

Gene Summary: Enables UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including positive regulation of reticulophagy; regulation of intracellular signal transduction; and regulation of primary metabolic process. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of proteasomal ubiquitin-dependent protein catabolic process; and response to endoplasmic reticulum stress. Located in cytoplasm; nucleus; and site of double-strand break. Part of protein-containing complex. Is active in endoplasmic reticulum membrane and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06864 UFL1 Knockout cell line (HeLa) Human UFL1 1:3~1:6 Negative Online Inquiry
KO06865 UFL1 Knockout cell line (HCT 116) Human UFL1 1:2~1:4 Negative Online Inquiry
KO06866 UFL1 Knockout cell line (HEK293) Human UFL1 1:3~1:6 Negative Online Inquiry
KO06867 UFL1 Knockout cell line (A549) Human UFL1 1:3~1:4 Negative Online Inquiry

Background

UFL1 Gene Knockout Cell Lines are invaluable biological tools designed to explore the intricate roles of the UFL1 gene in various cellular processes. UFL1 (Ubiquitin-fold modifier 1) is known to be involved in various signal transduction pathways, including stress responses, translation, and protein turnover. These engineered cell lines feature a targeted disruption of the UFL1 gene, allowing researchers to study the resultant phenotypic effects and elucidate UFL1's role in cellular function and disease mechanisms.

The principle mechanism behind the UFL1 Gene Knockout Cell Lines involves the CRISPR-Cas9 gene-editing technology, which enables precise modifications to the target gene. This knockout approach not only facilitates the investigation of UFL1's biological functions but also aids in the understanding of its interactions with other key proteins implicated in pathologies such as cancer, neurodegenerative disorders, and metabolic syndromes. Researchers can perform loss-of-function studies to assess cellular responses under various experimental conditions, providing insights that are essential for developing novel therapeutic strategies.

From a scientific perspective, these cell lines hold significant potential in both basic and applied research settings. They are particularly useful in drug discovery processes, where characterizing the role of UFL1 in drug responses can lead to more effective treatment regimens. Additionally, these knockout models can be instrumental in the design of gene therapies aimed at correcting malfunctioning pathways associated with the UFL1 gene.

What sets our UFL1 Gene Knockout Cell Lines apart from existing alternatives is their high fidelity and specificity in gene disruption, alongside a robust validation process ensuring the reliability of experimental outcomes. The cell lines are designed to exhibit stable phenotypic changes, thus providing reproducible results that researchers can depend upon for their studies.

Researchers and clinicians increasingly recognize the value of UFL1 Gene Knockout Cell Lines in advancing the understanding of cellular mechanisms and potential therapeutic targets. By integrating state-of-the-art gene editing with well-established cellular models, our product empowers the scientific community to push the boundaries of genetic research.

At [Company Name], we are dedicated to providing cutting-edge biological products that drive innovation in research and clinical applications. Our expertise in genetic engineering and commitment to quality ensures that you have the best tools at your disposal for your scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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