Gene: UBE2R2
Official Full Name: ubiquitin conjugating enzyme E2 R2provided by HGNC
Gene Summary: Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12862 | UBE2R2 Knockout cell line (HeLa) | Human | UBE2R2 | 1:3~1:6 | Negative | Online Inquiry |
KO12863 | UBE2R2 Knockout cell line (HCT 116) | Human | UBE2R2 | 1:2~1:4 | Negative | Online Inquiry |
KO12864 | UBE2R2 Knockout cell line (HEK293) | Human | UBE2R2 | 1:3~1:6 | Negative | Online Inquiry |
KO12865 | UBE2R2 Knockout cell line (A549) | Human | UBE2R2 | 1:3~1:4 | Negative | Online Inquiry |
UBE2R2 Gene Knockout Cell Lines represent an innovative tool for cellular and molecular biology research. These engineered cell lines have undergone a precise genomic alteration, resulting in the knockout of the UBE2R2 gene, which encodes an important ubiquitin-conjugating enzyme. This enzyme is implicated in various cellular processes, including protein degradation, signal transduction, and cell cycle regulation. By removing UBE2R2’s functionality, researchers can investigate its role in fundamental biological pathways, disease models, and the cellular response to various stimuli.
The key mechanism behind the UBE2R2 knockout is CRISPR/Cas9 technology, which enables specific and efficient editing of genes. This technique provides unparalleled precision, allowing the targeted disruption of UBE2R2 to elucidate its impact on cellular functions such as proliferation, apoptosis, and responses to stressors or drug treatments. Researchers can utilize these cell lines to better understand the implications of UBE2R2 deletion in diseases, including cancer and neurodegenerative disorders, facilitating the development of novel therapeutic strategies.
In the realm of scientific importance, UBE2R2 knockout cell lines serve as vital models for exploration in both academic and pharmaceutical research settings. They enable the study of ubiquitination processes and the delineation of pathways involved in disease pathology. Compared to traditional knockout techniques, our UBE2R2 gene knockout cell lines offer enhanced stability and reproducibility, making them ideal for long-term experiments and facilitating high-throughput screening applications.
The unique advantage of our UBE2R2 knockout cell lines lies not only in their advanced genetic editing but also in their readiness for immediate application. These cell lines are thoroughly validated and characterized, providing confidence in experimental results. This product is invaluable for researchers seeking to advance their understanding of ubiquitin-related pathways and explore potential clinical applications in targeted therapies.
At our company, we pride ourselves on delivering high-quality biological products backed by extensive expertise in genetic engineering and cell line development. Our commitment to innovation and rigor ensures that researchers and clinicians have access to the tools they need to drive their studies forward.
Please note that all services are for research use only. Not intended for any clinical use.
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