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UBE2G2 Knockout Cell Lines

Gene: UBE2G2

Official Full Name: ubiquitin conjugating enzyme E2 G2provided by HGNC

Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03870 UBE2G2 Knockout cell line (HeLa) Human UBE2G2 1:3~1:6 Negative Online Inquiry
KO03871 UBE2G2 Knockout cell line (HCT 116) Human UBE2G2 1:2~1:4 Negative Online Inquiry
KO03872 UBE2G2 Knockout cell line (HEK293) Human UBE2G2 1:3~1:6 Negative Online Inquiry
KO03873 UBE2G2 Knockout cell line (A549) Human UBE2G2 1:3~1:4 Negative Online Inquiry

Background

UBE2G2 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the UBE2G2 gene, which encodes for an E2 ubiquitin-conjugating enzyme. This product serves as a powerful tool for researchers studying the role of ubiquitination in various cellular processes, including protein degradation, cell cycle regulation, and signal transduction pathways. By eliminating the UBE2G2 gene, these cell lines allow for detailed examination of the downstream impacts and compensatory mechanisms that may arise in the absence of this enzyme.

The key functions of UBE2G2 include its involvement in ubiquitin-proteasome-mediated protein degradation and its role in the regulation of various cellular pathways. In UBE2G2 knockout cells, researchers can assess the effects of altered protein turnover, providing insights into diseases characterized by aberrant ubiquitination processes, such as cancer and neurodegenerative disorders. This product can further facilitate the discovery of novel therapeutic targets by enabling scientists to observe how the lack of UBE2G2 impacts cellular responses, survival, and proliferation.

The scientific importance of UBE2G2 Gene Knockout Cell Lines lies in their versatile applications across basic and translational research. They can be utilized in drug discovery, toxicology studies, and the investigation of cellular stress responses. Compared to traditional models, these knockout cell lines provide a more precise system to dissect the intricate network of ubiquitin-mediated signaling pathways, facilitating more accurate and reproducible results.

One of the distinct advantages of our UBE2G2 Gene Knockout Cell Lines is their ease of use and reproducibility, validated through rigorous quality control standards. Researchers will find that these cell lines maintain consistent phenotypic traits and growth characteristics that are essential for experimental integrity.

By investing in UBE2G2 Gene Knockout Cell Lines, researchers, and clinicians can gain valuable insights into the complexities of cellular regulation and disease mechanisms, ultimately influencing the development of innovative therapeutic strategies. Our company prides itself on delivering high-quality, genetically engineered cell lines developed by experts in the field, ensuring that our clients receive reliable and relevant tools for advancing their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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