Gene: UBE2E1
Official Full Name: ubiquitin conjugating enzyme E2 E1provided by HGNC
Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12878 | UBE2E1 Knockout cell line (HeLa) | Human | UBE2E1 | 1:3~1:6 | Negative | Online Inquiry |
KO12879 | UBE2E1 Knockout cell line (HCT 116) | Human | UBE2E1 | 1:2~1:4 | Negative | Online Inquiry |
KO12880 | UBE2E1 Knockout cell line (HEK293) | Human | UBE2E1 | 1:3~1:6 | Negative | Online Inquiry |
KO12881 | UBE2E1 Knockout cell line (A549) | Human | UBE2E1 | 1:3~1:4 | Negative | Online Inquiry |
UBE2E1 Gene Knockout Cell Lines are expertly engineered cellular models that enable the study of the UBE2E1 gene, which encodes a crucial E2 ubiquitin-conjugating enzyme involved in post-translational modification processes. By utilizing CRISPR-Cas9 technology, these cell lines have had the UBE2E1 gene effectively disrupted, thereby facilitating in-depth investigations into the role of UBE2E1 in cellular signaling, gene regulation, and protein degradation.
The primary function of these knockout cell lines lies in their capacity to elucidate the molecular mechanisms of ubiquitination, specifically how the absence of the UBE2E1 enzyme can alter protein homeostasis and influence various signaling pathways. Researchers can utilize these cell lines to explore the implications of UBE2E1 deficiency in cellular stress responses, aging processes, and pathophysiological conditions, including cancer and neurodegenerative diseases.
In both research and clinical settings, the UBE2E1 Gene Knockout Cell Lines serve as invaluable tools, allowing scientists to unlock potential therapeutic targets and biomarkers associated with UBE2E1-mediated pathways. This creates significant opportunities for drug development as well as the discovery of novel treatment modalities tailored to specific diseases.
Unlike traditional methods that often rely on transient gene silencing or less reliable inhibition, these knockout cell lines provide a more stable and reproducible platform for experimental validation. The specificity and robustness of this model system ensure high fidelity in results, reducing variability and enhancing experimental accuracy.
By utilizing UBE2E1 Gene Knockout Cell Lines, researchers and clinicians gain unparalleled access to a sophisticated resource that propels the understanding of ubiquitin biology. Our company brings extensive expertise in cell line development and gene editing technologies, ensuring the highest quality and performance standards in our product offerings. With our commitment to advancing research and healthcare solutions, we empower the scientific community to address challenging biological questions and develop innovative therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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