Gene: TUSC2
Official Full Name: tumor suppressor 2, mitochondrial calcium regulatorprovided by HGNC
Gene Summary: Predicted to be involved in inflammatory response and regulation of mitochondrial membrane potential. Predicted to act upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05121 | TUSC2 Knockout cell line (HeLa) | Human | TUSC2 | 1:3~1:6 | Negative | Online Inquiry |
KO05122 | TUSC2 Knockout cell line (HCT 116) | Human | TUSC2 | 1:2~1:4 | Negative | Online Inquiry |
KO05123 | TUSC2 Knockout cell line (HEK293) | Human | TUSC2 | 1:3~1:6 | Negative | Online Inquiry |
KO05124 | TUSC2 Knockout cell line (A549) | Human | TUSC2 | 1:3~1:4 | Negative | Online Inquiry |
TUSC2 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the expression of the TUSC2 gene, which is implicated in various forms of cancer suppression. These cell lines serve as invaluable tools for researchers seeking to elucidate the biological role of TUSC2, particularly its function in tumor suppression and its pathway interactions. The knockout mechanism typically employs CRISPR-Cas9 technology, allowing for precise editing of the genome to create a loss-of-function model that mimics the genetic alterations found in tumorigenesis.
The primary function of TUSC2 gene knockout cell lines is to facilitate the study of cellular processes such as differentiation, proliferation, and apoptosis in the context of TUSC2 deficiency. By examining these mechanisms, researchers can gain insights into how TUSC2 loss contributes to the progression of malignancies. Furthermore, these cell lines can be employed in drug screening assays to identify potential therapeutic agents that restore TUSC2 function or counteract its loss.
The scientific importance of TUSC2 Gene Knockout Cell Lines extends to both research and clinical applications. In the research arena, these models are essential for in-depth studies on tumor biology and the identification of prognostic biomarkers. Clinically, they hold potential in personalized medicine, aiding in the development of targeted therapies specific to tumors with TUSC2 mutations.
Unlike alternative models, TUSC2 Gene Knockout Cell Lines offer unparalleled specificity in mimicking the genetic landscape of cancer cell types, ensuring that results are more reflective of disease mechanisms. Their reproducibility, coupled with the well-characterized nature of CRISPR technology, enhances their reliability for experimentation.
For researchers and clinicians focusing on cancer biology, TUSC2 Gene Knockout Cell Lines represent an essential asset, bridging the gap between basic science and practical application. Investing in these models not only bolsters research capabilities but also contributes to advancing therapeutic strategies aimed at combating cancer.
Our company specializes in providing high-quality genetic tools and cellular models, backed by extensive expertise in the field of molecular biology and genetics, ensuring that researchers receive cutting-edge products to facilitate their work.
Please note that all services are for research use only. Not intended for any clinical use.
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