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TSEN34 Knockout Cell Lines

Gene: TSEN34

Official Full Name: tRNA splicing endonuclease subunit 34provided by HGNC

Gene Summary: This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12993 TSEN34 Knockout cell line (HeLa) Human TSEN34 1:3~1:6 Negative Online Inquiry
KO12994 TSEN34 Knockout cell line (HCT 116) Human TSEN34 1:2~1:4 Negative Online Inquiry
KO12995 TSEN34 Knockout cell line (HEK293) Human TSEN34 1:3~1:6 Negative Online Inquiry
KO12996 TSEN34 Knockout cell line (A549) Human TSEN34 1:3~1:4 Negative Online Inquiry

Background

TSEN34 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the role of the TSEN34 gene, which is implicated in various biological processes including tRNA modification and mitochondrial function. These cell lines have been generated using state-of-the-art CRISPR-Cas9 gene editing technology, allowing for precise knockout of the TSEN34 gene, thereby facilitating the study of its function and associated pathways in both health and disease contexts.

The primary function of TSEN34 knockout cell lines is to create a controlled environment where researchers can elucidate the biological impacts of the TSEN34 gene loss. By observing changes in cellular behavior, gene expression profiles, and metabolic pathways in these knockout models, scientists are equipped to draw connections between TSEN34 dysfunction and disorders such as mitochondrial diseases or certain forms of cancer. This functional insight is critical for advancing our understanding of gene regulation and interaction in complex biological systems.

In research and clinical settings, TSEN34 knockout cell lines hold significant importance, as they provide invaluable models for drug discovery, mechanism of action studies, and therapeutic interventions targeting mitochondrial signaling pathways. Their utility extends to genetic screening and biomarker discovery, making them a versatile tool for both basic and applied science.

What sets our TSEN34 knockout cell lines apart from alternative models is the rigor of our gene editing process, ensuring high specificity and efficiency. Additionally, each clone is characterized at a genomic and phenotypic level, providing reassurance regarding the reproducibility and reliability of results. These lines offer researchers a powerful resource to gain deeper insights into gene function, tailored to their specific experimental needs.

Researchers and clinicians seeking innovative solutions in gene function studies will find our TSEN34 Gene Knockout Cell Lines to be an indispensable asset. The value of this product lies not only in the potential discoveries it enables but also in enhancing the translational applicability of research outcomes into clinical practice. Our company has a proven track record in delivering high-quality biological products, underpinned by cutting-edge technological advancements, a commitment to scientific excellence, and a focus on supporting our clients’ research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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