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TNIK Knockout Cell Lines

Gene: TNIK

Official Full Name: TRAF2 and NCK interacting kinaseprovided by HGNC

Gene Summary: Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29984 TNIK Knockout cell line (HeLa) Human TNIK 1:3~1:6 Negative Online Inquiry
KO29985 TNIK Knockout cell line (HCT 116) Human TNIK 1:2~1:4 Negative Online Inquiry
KO29986 TNIK Knockout cell line (HEK293) Human TNIK 1:3~1:6 Negative Online Inquiry
KO29987 TNIK Knockout cell line (A549) Human TNIK 1:3~1:4 Negative Online Inquiry

Background

TNIK Gene Knockout Cell Lines represent a groundbreaking advancement in molecular biology and genetic research. These cell lines have been purposefully engineered to eliminate the expression of the TNIK (TRAF2 and NCK interacting protein kinase) gene, allowing researchers a unique platform to study the role of TNIK in various cellular processes, including cell signaling, proliferation, and apoptosis.

Functionally, TNIK plays a crucial role in Wnt signaling pathways and is integral in maintaining cellular homeostasis. By utilizing gene knockout technology, these cell lines facilitate the investigation of TNIK’s contributions to disease mechanisms, particularly in oncogenesis and neurodegeneration. The precise knockout of the TNIK gene enables researchers to observe phenotypic changes and dissect molecular pathways that are otherwise masked in wild-type cell models.

The scientific importance of TNIK Gene Knockout Cell Lines is underscored by their utility in both basic and applied research settings. These cell lines are vital for elucidating signaling pathways involved in cancer and developmental disorders, thus serving as a valuable tool for drug discovery and therapeutic interventions.

Compared to other cell lines, TNIK Gene Knockout Cell Lines differentiate themselves by providing a high-fidelity model that closely mimics the loss-of-function mutations observed in various cancers and other diseases. This specificity enhances the predictive value of experimental results, thereby improving translational research and therapeutic outcomes.

For researchers and clinicians aiming to delve into the intricacies of TNIK-related pathways, the availability of these knockout models is invaluable. They offer a reliable means to conduct functional assays, screen potential drug candidates, and explore genetic interventions with tangible clinical relevance.

Our company specializes in developing high-quality biological products that meet the advanced needs of the scientific community. With a commitment to innovation and excellence, we ensure that our TNIK Gene Knockout Cell Lines are validated and optimized for a range of experimental applications, further empowering researchers to drive discoveries in genetics and therapeutics.

Please note that all services are for research use only. Not intended for any clinical use.

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