Gene: TNFRSF19
Official Full Name: TNF receptor superfamily member 19provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06506 | TNFRSF19 Knockout cell line (HeLa) | Human | TNFRSF19 | 1:3~1:6 | Negative | Online Inquiry |
KO06507 | TNFRSF19 Knockout cell line (HEK293) | Human | TNFRSF19 | 1:3~1:6 | Negative | Online Inquiry |
KO06508 | TNFRSF19 Knockout cell line (A549) | Human | TNFRSF19 | 1:3~1:4 | Negative | Online Inquiry |
TNFRSF19 Gene Knockout Cell Lines represent a cutting-edge tool in cellular biology, specifically designed to explore the biological roles of the tumor necrosis factor receptor superfamily member 19 (TNFRSF19) in various physiological and pathological contexts. These cell lines have been genetically engineered to deactivate the TNFRSF19 gene, creating a powerful platform for researchers to elucidate the receptor's contributions to immune responses, inflammation, and potential implications in cancer biology.
The primary function of TNFRSF19 is to mediate signaling pathways associated with immune cell activation and regulation. By utilizing the knockout cell lines, researchers can investigate the downstream effects of TNFRSF19 in cellular signaling and its role in disease processes. This approach allows for a clearer understanding of how the absence of this receptor affects cellular behavior, including proliferation, apoptosis, and cytokine production, facilitating the development of targeted therapies.
In scientific research and clinical applications, the importance of TNFRSF19 Gene Knockout Cell Lines cannot be overstated. They serve as crucial models for studying immune regulation and the impact of TNFRSF19 on disorders such as autoimmune diseases and malignancies. These cell lines enable researchers to validate therapeutic targets, screen potential drug candidates, and develop personalized medicine approaches based on individual immunological profiles.
Compared to alternative methods like siRNA or pharmacological inhibitors, TNFRSF19 knockout cell lines offer long-term stability and consistent expression profiles, ensuring reliable data over extended research periods. This robust reproducibility is essential for generating compelling experimental outcomes, which is of paramount importance in both academic and pharmaceutical settings.
Researchers and clinicians will find substantial value in these cell lines due to their ability to provide nuanced insights into TNFRSF19-related pathways, presenting opportunities for novel therapeutic interventions. By leveraging the TNFRSF19 Gene Knockout Cell Lines, teams can expedite their research initiatives, contribute to significant scientific advancements, and ultimately improve patient care outcomes.
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