Gene: TNFRSF10C
Official Full Name: TNF receptor superfamily member 10cprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33848 | TNFRSF10C Knockout cell line (HCT 116) | Human | TNFRSF10C | 1:2~1:4 | Negative | Online Inquiry |
KO33849 | TNFRSF10C Knockout cell line (HEK293) | Human | TNFRSF10C | 1:3~1:6 | Negative | Online Inquiry |
KO33850 | TNFRSF10C Knockout cell line (A549) | Human | TNFRSF10C | 1:3~1:4 | Negative | Online Inquiry |
TNFRSF10C Gene Knockout Cell Lines are engineered cellular models that effectively lack the tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) gene, known to be crucial in regulating apoptosis and immune responses. By employing advanced gene editing techniques, such as CRISPR/Cas9, these cell lines provide invaluable tools for studying the roles of TNFRSF10C in various biological processes and disease states.
The primary function of TNFRSF10C is to modulate the apoptotic pathways, influencing cell survival and immune system functionality. By knocking out this gene, researchers can elucidate its specific involvement in cell signaling processes, potentially identifying new therapeutic targets for cancer and autoimmune diseases. These cell lines allow for detailed analysis of the biochemical interactions that occur in normal versus pathological conditions, enabling a deeper understanding of fundamental cellular mechanisms.
From a scientific standpoint, the TNFRSF10C Gene Knockout Cell Lines hold considerable significance in both research and clinical applications. Researchers can utilize these cell models to dissect the molecular pathways associated with TNFRSF10C, facilitating the development of novel treatment strategies. This model system is particularly beneficial for drug discovery, toxicity testing, and understanding disease mechanisms.
The advantages of our TNFRSF10C Knockout Cell Lines over alternative models include their high specificity and reproducibility, as well as the extensive validation of their genetic modification. Unlike primary cell lines that can exhibit heterogeneity and variability, our knockout models provide a consistent baseline for comparisons across experiments, ultimately leading to more reliable and impactful results.
For researchers and clinicians seeking to innovate and push the boundaries of their studies, our TNFRSF10C Gene Knockout Cell Lines serve as essential resources. They empower users to explore cutting-edge research avenues while addressing significant health challenges. With years of expertise in the creation and supply of biological products, our company is committed to providing quality and specificity that meet the demanding needs of modern scientific investigation.
Please note that all services are for research use only. Not intended for any clinical use.
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