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TMPO Knockout Cell Lines

Gene: TMPO

Official Full Name: thymopoietinprovided by HGNC

Gene Summary: Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01718 TMPO Knockout cell line (HeLa) Human TMPO 1:3~1:6 Negative Online Inquiry
KO01719 TMPO Knockout cell line (HCT 116) Human TMPO 1:2~1:4 Negative Online Inquiry
KO01720 TMPO Knockout cell line (HEK293) Human TMPO 1:3~1:6 Negative Online Inquiry
KO01721 TMPO Knockout cell line (A549) Human TMPO 1:3~1:4 Negative Online Inquiry

Background

TMPO Gene Knockout Cell Lines are advanced biological research tools designed to facilitate the in-depth study of the TMPO gene and its associated functions. These cell lines are created using targeted gene editing techniques, such as CRISPR/Cas9, to specifically disrupt the endogenous expression of the TMPO gene. As a result, researchers can investigate the functional consequences of gene loss, shedding light on the biological roles of TMPO in various cellular processes, including nuclear architecture, cellular signaling, and chromosomal stability.

The primary mechanism behind the use of TMPO Gene Knockout Cell Lines involves the creation of a genetic landscape that mimics loss-of-function conditions, allowing scientists to discern the pathways influenced by TMPO. This is particularly important in research settings focused on cancer biology, as mutations or aberrant expression of TMPO have been implicated in several malignancies. By utilizing these cell lines, researchers can effectively dissect the molecular pathways dependent on TMPO, providing insights into potential therapeutic targets.

The scientific importance of TMPO Gene Knockout Cell Lines extends to diverse applications ranging from basic research on gene function to translational studies aimed at developing novel cancer therapies. They offer a unique platform for studying cellular responses to stress, differentiation, and senescence, making them versatile tools for researchers across various fields.

When compared to alternative systems, TMPO Gene Knockout Cell Lines provide a more precise and controllable experimental environment. Unlike traditional knockdown methods, which often lead to incomplete gene silencing, our knockout cell lines ensure a complete loss of TMPO expression, resulting in more reproducible and reliable data. This specificity fosters a deeper understanding of gene function and its implications in disease pathology.

For researchers and clinicians, the value of TMPO Gene Knockout Cell Lines lies in their ability to propel discoveries that can lead to innovative treatments and diagnostics. By offering a clear picture of TMPO's role, these cell lines pave the way for novel therapeutic strategies targeting related pathways.

As a company dedicated to providing high-quality biological products, we pride ourselves on our extensive expertise in gene editing and cellular models, ensuring that our TMPO Gene Knockout Cell Lines meet the rigorous standards of modern scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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