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TMEM59 Knockout Cell Lines

Gene: TMEM59

Official Full Name: transmembrane protein 59provided by HGNC

Gene Summary: This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33144 TMEM59 Knockout cell line (HeLa) Human TMEM59 1:3~1:6 Negative Online Inquiry
KO33145 TMEM59 Knockout cell line (HCT 116) Human TMEM59 1:2~1:4 Negative Online Inquiry
KO33146 TMEM59 Knockout cell line (HEK293) Human TMEM59 1:3~1:6 Negative Online Inquiry
KO33147 TMEM59 Knockout cell line (A549) Human TMEM59 1:3~1:4 Negative Online Inquiry

Background

TMEM59 Gene Knockout Cell Lines are engineered cellular models designed to facilitate the study and elucidation of the TMEM59 gene's biological functions. By utilizing CRISPR-Cas9 gene-editing technology, these knockout cell lines effectively disable the TMEM59 gene, providing a powerful platform for investigating its role in cellular processes such as protein trafficking, cellular signaling, and stress responses.

The primary mechanism of action involves the precise introduction of double-strand breaks in the TMEM59 gene sequence, leading to the disruption of normal gene function. As a result, researchers can observe cellular phenotypes associated with TMEM59 deficiency, which may include alterations in cell proliferation, migration, and apoptosis. Understanding these pathways is critical, especially given that TMEM59 has been implicated in various diseases, including certain cancers and neurodegenerative disorders.

The scientific importance of TMEM59 Gene Knockout Cell Lines extends to both fundamental research and translational studies. In research settings, these models provide insights into gene function and regulatory networks, while clinical applications may include novel therapeutic strategies targeting TMEM59-associated pathways. This unique resource facilitates high-throughput screening for potential drug candidates and the development of precision medicine approaches.

Compared to conventional cell lines that retain full gene function, TMEM59 knockout lines offer targeted insights into the underlying biological processes influenced by TMEM59. Their specificity enables researchers to make more informed decisions regarding experimental design and interpretation of data related to gene function.

Ultimately, the value of TMEM59 Gene Knockout Cell Lines lies in their ability to advance research and clinical outcomes by providing a robust tool for understanding gene function in health and disease. Our company is committed to delivering high-quality, innovative biological products and services, backed by our expertise in gene editing and molecular biology, ensuring researchers have access to essential tools that drive scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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