Gene: TMEM181
Official Full Name: transmembrane protein 181provided by HGNC
Gene Summary: The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20114 | TMEM181 Knockout cell line (HeLa) | Human | TMEM181 | 1:3~1:6 | Negative | Online Inquiry |
KO20115 | TMEM181 Knockout cell line (HCT 116) | Human | TMEM181 | 1:2~1:4 | Negative | Online Inquiry |
KO20116 | TMEM181 Knockout cell line (HEK293) | Human | TMEM181 | 1:3~1:6 | Negative | Online Inquiry |
KO20117 | TMEM181 Knockout cell line (A549) | Human | TMEM181 | 1:3~1:4 | Negative | Online Inquiry |
TMEM181 Gene Knockout Cell Lines are specifically engineered cellular models designed to enable researchers to study the functions and impacts of the TMEM181 gene in various biological contexts. These cell lines utilize advanced CRISPR/Cas9 gene editing techniques to effectively disrupt the expression of the TMEM181 gene, allowing for the observation of phenotypic changes and cellular behaviors that may result from its ablation. By creating a precise knockout of TMEM181, researchers can investigate its role in cellular processes such as signal transduction, development, and disease progression.
The key mechanisms of TMEM181 knockouts work by introducing specific double-strand breaks in the gene’s DNA sequence, followed by the cellular repair process, which can lead to insertions or deletions that disrupt normal transcription. This loss of function provides invaluable insights into gene function and regulation, making these knockout cell lines critical tools for understanding the physiological and pathophysiological roles of TMEM181.
The scientific importance of these cell lines extends across diverse biological research fields, including cancer biology, neurobiology, and developmental biology. They serve as model systems for drug screening, genetic interaction studies, and the validation of therapeutic targets, bridging the gap between basic research and clinical application.
TMEM181 Gene Knockout Cell Lines offer several unique advantages over traditional models. Their precision in gene editing ensures reproducibility and reliability in experimental design, while the ability to manipulate other pathways simultaneously enhances their versatility. Moreover, these cell lines are readily adaptable for high-throughput screening, expediting the research process without compromising data integrity.
Primary users of these cell lines, including researchers and clinicians, will find immense value in their potential to elucidate complex biological mechanisms, leading to advancements in therapeutic strategies and biomarker discovery. The production of these knockout models is backed by our company's extensive experience in genetic engineering and cell line development, underscoring our commitment to providing high-quality tools for scientific advancement. Our expertise ensures that TMEM181 Gene Knockout Cell Lines will be a valuable addition to any research program aimed at unraveling the complexities of gene function and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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