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TMEM168 Knockout Cell Lines

Gene: TMEM168

Official Full Name: transmembrane protein 168provided by HGNC

Gene Summary: Enables sodium channel regulator activity. Predicted to act upstream of or within regulation of ubiquitin-dependent protein catabolic process and regulation of voltage-gated sodium channel activity. Located in nuclear membrane and transport vesicle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13224 TMEM168 Knockout cell line (HeLa) Human TMEM168 1:3~1:6 Negative Online Inquiry
KO13225 TMEM168 Knockout cell line (HCT 116) Human TMEM168 1:2~1:4 Negative Online Inquiry
KO13226 TMEM168 Knockout cell line (HEK293) Human TMEM168 1:3~1:6 Negative Online Inquiry
KO13227 TMEM168 Knockout cell line (A549) Human TMEM168 1:3~1:4 Negative Online Inquiry

Background

TMEM168 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the TMEM168 gene's biological functions and its role in various cellular processes. Utilizing advanced CRISPR/Cas9 technology, these cell lines exhibit a complete knockout of the TMEM168 gene, allowing researchers to investigate the resultant phenotypic changes and elucidate the gene’s involvement in critical pathways, including those related to cellular stress responses, autophagy, and membrane trafficking.

The primary mechanism of action for these knockout cell lines hinges on the gene editing capability of CRISPR/Cas9, which enables precise alterations in the genomic DNA. By selectively removing the TMEM168 gene, researchers can dissect its contributions to cellular morphology, metabolic functions, and responses to external stimuli, providing a comprehensive understanding of its physiological roles.

Significantly, the scientific importance of TMEM168 Gene Knockout Cell Lines extends to various research areas. In clinical settings, these models are invaluable for exploring the implications of TMEM168 in disease processes, particularly neurodegenerative disorders where membrane trafficking dysregulation is implicated. This allows for the identification of potential therapeutic targets and contributes to the development of treatment strategies.

Compared to alternatives, such as traditional RNA interference techniques or non-specific knockout models, our TMEM168 Gene Knockout Cell Lines provide unparalleled specificity and efficiency. The use of CRISPR technology not only eliminates the gene of interest but also minimizes off-target effects, ensuring more reliable and reproducible research outcomes.

For researchers and clinicians, these cell lines represent a vital resource for advancing our understanding of the complexities of gene function and disease mechanisms. They pave the way for innovative discoveries that can potentially translate into clinical applications, enhancing patient care.

Our company is committed to providing high-quality biological research tools, supported by extensive expertise in gene editing technologies. By offering TMEM168 Gene Knockout Cell Lines, we empower scientists to explore the intricacies of genetic regulation and its impact on health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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