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TMED1 Knockout Cell Lines

Gene: TMED1

Official Full Name: transmembrane p24 trafficking protein 1provided by HGNC

Gene Summary: This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31315 TMED1 Knockout cell line (HeLa) Human TMED1 1:3~1:6 Negative Online Inquiry
KO31316 TMED1 Knockout cell line (HCT 116) Human TMED1 1:2~1:4 Negative Online Inquiry
KO31317 TMED1 Knockout cell line (HEK293) Human TMED1 1:3~1:6 Negative Online Inquiry
KO31318 TMED1 Knockout cell line (A549) Human TMED1 1:3~1:4 Negative Online Inquiry

Background

TMED1 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the function of the TMED1 gene, which is critical for the transport and processing of proteins within the endoplasmic reticulum. By utilizing CRISPR-Cas9 gene editing technology, these cell lines allow for precise knockout of TMED1, effectively enabling researchers to study its biological role and contribution to various cellular processes.

The key function of the TMED1 Gene Knockout Cell Lines lies in their ability to mimic pathological conditions observed in diseases linked to protein misfolding and trafficking, such as neurodegenerative disorders and certain cancers. This model provides invaluable insights into the protein processing machinery and facilitates the exploration of therapeutic targets by elucidating the molecular consequences of TMED1 deficiency.

In research settings, these knockout cell lines serve as powerful tools for functional genomics, allowing scientists to investigate cellular responses under controlled conditions. Their application extends to drug discovery, wherein researchers can screen compounds to identify those that specifically modulate the effects of TMED1 loss, thereby offering a pathway to novel therapeutic interventions.

Compared to traditional cell lines, TMED1 Gene Knockout Cell Lines stand out due to their high specificity and relevance to human disease mechanisms, making them more advantageous for translational research. Their ability to provide a clearer understanding of the impact of TMED1 deletion enhances the predictive power of experimental results.

For researchers and clinicians keen on advancing their understanding of protein dynamics and related disorders, these knockout cell lines present a unique opportunity to uncover novel insights and potential treatment strategies. Our company prides itself on its expertise in developing cutting-edge cellular models, ensuring that you receive high-quality, validated products that facilitate groundbreaking scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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