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TIMM17B Knockout Cell Lines

Gene: TIMM17B

Official Full Name: translocase of inner mitochondrial membrane 17Bprovided by HGNC

Gene Summary: This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32081 TIMM17B Knockout cell line (HeLa) Human TIMM17B 1:3~1:6 Negative Online Inquiry
KO32082 TIMM17B Knockout cell line (HCT 116) Human TIMM17B 1:2~1:4 Negative Online Inquiry
KO32083 TIMM17B Knockout cell line (HEK293) Human TIMM17B 1:3~1:6 Negative Online Inquiry
KO32084 TIMM17B Knockout cell line (A549) Human TIMM17B 1:3~1:4 Negative Online Inquiry

Background

TIMM17B Gene Knockout Cell Lines represent a groundbreaking advancement in the field of molecular biology and genetics. These engineered cell lines are specifically designed to disable the TIMM17B gene, which encodes a crucial component of the mitochondrial translocase of the inner membrane. The loss of TIMM17B function has significant implications for mitochondrial dynamics, protein import, and cellular metabolism, making these knockout cell lines an essential tool for researchers investigating mitochondrial disorders, bioenergetics, and cell signaling pathways.

The primary function of TIMM17B Gene Knockout Cell Lines is to facilitate the study of mitochondrial biogenesis and dysfunction. By providing a model system where TIMM17B is silenced, researchers can elucidate the gene's role in mitochondrial protein import and its impact on cellular energy production. Mechanistically, the knockout cell lines help in assessing changes in mitochondrial morphology, apoptosis regulation, and metabolic flexibility, thereby providing crucial insights into the underlying pathophysiology of various diseases, including neurodegeneration and cancer.

The scientific importance of these knockout cell lines extends to their applications in both basic research and clinical settings. They serve as a vital resource for drug screening assays targeting mitochondrial-related diseases and allow for the evaluation of therapeutic interventions that restore mitochondrial function. In addition, these cell lines can be utilized to study the implications of TIMM17B dysregulation in specific conditions, enhancing our understanding of complex cellular processes and disease mechanisms.

When compared to other products in the market, TIMM17B Gene Knockout Cell Lines offer several advantages. They undergo rigorous validation to confirm successful gene knockout, ensuring reliable and reproducible results. Furthermore, these cell lines are compatible with various experimental protocols, making them versatile tools for a wide range of studies.

For researchers and clinicians focused on unraveling the intricacies of mitochondrial biology, the TIMM17B Gene Knockout Cell Lines are invaluable. They provide a unique opportunity for groundbreaking discoveries that can lead to innovative therapeutic strategies.

Our company prides itself on its expertise in providing high-quality biological products. By focusing on precision gene editing and cell line development, we aim to support the scientific community with advanced tools that drive impactful research and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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