Gene: TECPR2
Official Full Name: tectonin beta-propeller repeat containing 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32543 | TECPR2 Knockout cell line (HeLa) | Human | TECPR2 | 1:3~1:6 | Negative | Online Inquiry |
KO32544 | TECPR2 Knockout cell line (HCT 116) | Human | TECPR2 | 1:2~1:4 | Negative | Online Inquiry |
KO32545 | TECPR2 Knockout cell line (HEK293) | Human | TECPR2 | 1:3~1:6 | Negative | Online Inquiry |
KO32546 | TECPR2 Knockout cell line (A549) | Human | TECPR2 | 1:3~1:4 | Negative | Online Inquiry |
TECPR2 Gene Knockout Cell Lines are genetically modified cell lines in which the TECPR2 gene has been precisely disrupted, allowing researchers to investigate the biological functions and regulatory pathways associated with this key gene. TECPR2 (tecpin family member 2) is implicated in various cellular processes, including autophagy, immune response, and neurodevelopment. By employing a CRISPR-Cas9 or homologous recombination approach, these knockout cell lines serve as a vital tool for studying the loss-of-function effects of TECPR2 in various cellular contexts.
The primary mechanism of action lies in the complete ablation of TECPR2 expression, enabling the observation of phenotypic alterations that reveal new insights into its role in cellular homeostasis and disease mechanisms. Researchers can monitor the impacts on autophagic flux, protein degradation pathways, and stress responses, making these cell lines valuable in elucidating pathophysiological conditions such as neurodegenerative disorders or immune-related diseases.
The scientific importance of TECPR2 Gene Knockout Cell Lines is underscored by their potential applications in both basic and translational research settings. For example, studying these cell lines can lead to breakthroughs in understanding foundational biological processes that govern cancer progression or identifying novel therapeutic targets in diseases where TECPR2 is dysregulated.
Compared to other options, such as overexpression models or wild-type cell lines, the TECPR2 knockout variety offers a more relevant context for examining gene function. This specificity facilitates better interpretation and translational relevance for clinical scenarios, allowing researchers to gain deeper insights into the gene's roles in various biological pathways.
In conclusion, TECPR2 Gene Knockout Cell Lines represent an indispensable resource for researchers and clinicians seeking to explore the mechanistic underpinnings of TECPR2-related biological processes. Our company specializes in high-quality, validated genetic models, ensuring you have the precise tools necessary for groundbreaking research. With a commitment to excellence, we stand by our products, dedicated to advancing scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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