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TCF12 Knockout Cell Lines

Gene: TCF12

Official Full Name: transcription factor 12provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05103 TCF12 Knockout cell line (HeLa) Human TCF12 1:3~1:6 Negative Online Inquiry
KO05104 TCF12 Knockout cell line (HCT 116) Human TCF12 1:2~1:4 Negative Online Inquiry
KO05105 TCF12 Knockout cell line (HEK293) Human TCF12 1:3~1:6 Negative Online Inquiry
KO05106 TCF12 Knockout cell line (A549) Human TCF12 1:3~1:4 Negative Online Inquiry

Background

TCF12 Gene Knockout Cell Lines represent a groundbreaking tool in molecular biology, serving as a vital resource for studying the role of the TCF12 gene, also known as Transcription Factor 12, in various biological processes. These genetically modified cell lines have been meticulously engineered using CRISPR/Cas9 technology to create a complete knockout of TCF12, which allows researchers to assess its essential functions and interactions within cellular pathways.

The TCF12 protein is critically involved in regulating gene expression and cellular differentiation. By utilizing these knockout cell lines, researchers can explore the consequences of TCF12 deficiency, examining alterations in gene regulatory networks and cellular behaviors, such as proliferation, apoptosis, and stem cell differentiation. This makes these cell lines invaluable for elucidating mechanisms underlying developmental biology, cancer progression, and regenerative medicine.

The scientific importance of TCF12 Gene Knockout Cell Lines extends to multiple research and clinical applications. For instance, these models can be employed to investigate TCF12's role in diseases such as hematological malignancies, where its dysregulation can contribute to tumorigenesis. Furthermore, these cell lines can facilitate drug discovery by serving as a screening platform for potential therapeutics aiming to modulate TCF12-related pathways.

One of the distinct advantages of using TCF12 Gene Knockout Cell Lines over alternative models is the precision of the gene-editing technology employed, ensuring a complete and specific knockout that minimizes off-target effects. Additionally, researchers benefit from high reproducibility and consistent performance in experiments, enhancing the reliability of their findings.

Researchers and clinicians will find immense value in these cell lines as they provide a platform for exploring fundamental biological questions while also expanding the potential for translational research. The data derived from studies utilizing TCF12 knockout models could lead to novel therapeutic strategies or biomarkers for various pathologies.

With a proven track record in gene editing and a commitment to advancing scientific discovery, our company excels in providing high-quality biological research products. Our expertise and dedication to innovation enable us to support the scientific community in unlocking the complexities of gene functionality and disease mechanisms.

Please note that all services are for research use only. Not intended for any clinical use.

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