Gene: TBC1D8B
Official Full Name: TBC1 domain family member 8Bprovided by HGNC
Gene Summary: This gene encodes a protein with a TBC (Tre-2/Bub2/CDC16) domain. Some mammalian proteins with this domain have been shown to function as Rab-GAPs by binding to specific Rab proteins and affecting their GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13551 | TBC1D8B Knockout cell line (HeLa) | Human | TBC1D8B | 1:3~1:6 | Negative | Online Inquiry |
KO13552 | TBC1D8B Knockout cell line (HCT 116) | Human | TBC1D8B | 1:2~1:4 | Negative | Online Inquiry |
KO13553 | TBC1D8B Knockout cell line (HEK293) | Human | TBC1D8B | 1:3~1:6 | Negative | Online Inquiry |
KO13554 | TBC1D8B Knockout cell line (A549) | Human | TBC1D8B | 1:3~1:4 | Negative | Online Inquiry |
TBC1D8B Gene Knockout Cell Lines are specialized cellular models engineered to express a loss-of-function mutation in the TBC1D8B gene, a crucial component involved in intracellular signaling and membrane dynamics. These knockout cell lines enable researchers to investigate the biological roles of TBC1D8B, particularly in the context of cellular growth, metabolism, and endocytic processes. By systematically eliminating the expression of this gene, scientists can study the resultant phenotypic changes and elucidate the underlying molecular pathways that TBC1D8B influences.
The key mechanisms of action stem from the disruption of the protein encoded by the TBC1D8B gene, which has been implicated in modulating the activity of small GTPases involved in the regulation of endosomal trafficking. This disruption enables exploration into lipid metabolism, cellular signaling, and the mechanistic pathways of various diseases, particularly cancer and metabolic disorders. The TBC1D8B knockout model is thus invaluable for identifying potential therapeutic targets and biomarkers in these disease states.
The scientific significance of TBC1D8B Gene Knockout Cell Lines extends into multiple research and clinical applications, including drug discovery and validation, functional genomics, and mechanistic studies of disease pathology. Unlike standard cell lines, these knockout models provide a level of specificity and insight into the gene's functional dynamics, making them particularly valuable for researchers focused on translational science.
Compared to alternative models, TBC1D8B knockout cell lines offer unique advantages such as well-characterized genetic backgrounds, reproducibility, and ease of use in experiments that require rigorous control over gene expression. Moreover, they facilitate high-throughput screening and analyses, significantly accelerating the pace of discovery in areas such as therapeutic development.
For researchers and clinicians dedicated to understanding disease mechanisms or developing targeted therapies, TBC1D8B Gene Knockout Cell Lines serve as a pivotal tool, allowing for deeper insights that drive scientific advancement. At [Your Company Name], we are committed to providing high-quality biological products, and our expertise in genetic engineering ensures that you receive reliable and innovative solutions tailored to meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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