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TARBP2 Knockout Cell Lines

Gene: TARBP2

Official Full Name: TARBP2 subunit of RISC loading complexprovided by HGNC

Gene Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20596 TARBP2 Knockout cell line (HeLa) Human TARBP2 1:3~1:6 Negative Online Inquiry
KO20597 TARBP2 Knockout cell line (HCT 116) Human TARBP2 1:2~1:4 Negative Online Inquiry
KO20598 TARBP2 Knockout cell line (HEK293) Human TARBP2 1:3~1:6 Negative Online Inquiry
KO20599 TARBP2 Knockout cell line (A549) Human TARBP2 1:3~1:4 Negative Online Inquiry

Background

TARBP2 Gene Knockout Cell Lines are genetically engineered cell lines that provide researchers with the ability to study the functional role of the TARBP2 gene, which encodes for a protein critical in RNA-mediated processes, notably in the context of virus-host interactions and RNA silencing pathways. These knockout lines are produced using advanced CRISPR-Cas9 technology to achieve precise gene editing, resulting in a complete disruption of TARBP2 expression.

The primary function of these cell lines enables scientists to investigate the biological implications of TARBP2 loss, which is vital for understanding its role in various cellular pathways, particularly those involving antiviral responses and gene regulation mechanisms. This knockout model is essential for the exploration of novel therapeutic approaches targeting diseases where TARBP2 activity may be altered, including viral infections, cancers, and neurodegenerative disorders.

From a scientific standpoint, TARBP2 Gene Knockout Cell Lines hold immense value in both basic and applied research. In clinical settings, these models can aid in drug development and testing by providing a platform to assess the impact of therapeutic agents on cells lacking TARBP2, thereby elucidating essential biological responses that are critical for therapeutic efficacy.

Compared to traditional cell line models, our TARBP2 knockout lines offer unique advantages, including higher specificity and reproducibility in gene editing, reducing off-target effects and enhancing the reliability of experimental outcomes. This precision allows researchers to obtain clearer insights into gene function and potential pathways for intervention.

For researchers and clinicians, these cell lines represent a powerful tool for advancing knowledge in molecular biology and translational medicine. By offering an innovative product that addresses some of the most pressing questions in the field of gene function and disease, we position ourselves at the forefront of genetic research.

With extensive expertise in genetic engineering and cell line development, our company is committed to providing high-quality biological products that facilitate groundbreaking research and drive the discovery of novel therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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