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TACO1 Knockout Cell Lines

Gene: TACO1

Official Full Name: translational activator of cytochrome c oxidase Iprovided by HGNC

Gene Summary: This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22870 TACO1 Knockout cell line (HeLa) Human TACO1 1:3~1:6 Negative Online Inquiry
KO22871 TACO1 Knockout cell line (HCT 116) Human TACO1 1:2~1:4 Negative Online Inquiry
KO22872 TACO1 Knockout cell line (HEK293) Human TACO1 1:3~1:6 Negative Online Inquiry
KO22873 TACO1 Knockout cell line (A549) Human TACO1 1:3~1:4 Negative Online Inquiry

Background

TACO1 Gene Knockout Cell Lines are genetically engineered models designed to facilitate the in-depth study of the TACO1 gene's role in mitochondrial function and related pathways. TACO1, involved in mitochondrial protein synthesis, plays a crucial role in the assembly and maintenance of mitochondrial respiratory complexes. These knockout cell lines allow researchers to eliminate TACO1 expression selectively, providing insights into mitochondrial dynamics, energy metabolism, and the potential pathophysiological mechanisms underlying various mitochondrial diseases.

The key function of TACO1 Gene Knockout Cell Lines lies in their ability to recapitulate the cellular consequences of TACO1 deficiency. By analyzing these cells, researchers can assess alterations in mitochondrial morphology, changes in bioenergetics, and the impact on cellular homeostasis. The knockout model serves as a powerful tool for unraveling the molecular mechanisms by which TACO1 influences mitochondrial translation processes and its downstream effects on cellular health.

From a scientific standpoint, these cell lines hold significant applications in both basic research and clinical settings. They are invaluable for investigating the etiology of mitochondrial disorders, as well as for screening potential therapeutic compounds targeting mitochondrial dysfunction. Researchers can use these models to explore the biochemical pathways that may be altered in diseases like mitochondrial myopathy and provide a platform for future drug development strategies.

Compared to other knockout models, TACO1 Gene Knockout Cell Lines are uniquely differentiated by their specificity for the TACO1 gene, high fidelity of genetic modification, and the stability of the phenotype. This specificity allows for a more refined analysis of mitochondrial functions than more generalized knockout models. Additionally, the reproducibility and consistency in experimental outcomes provide researchers with reliable data, maximizing research efficiency.

For researchers and clinicians focused on mitochondrial biology and associated pathologies, TACO1 Gene Knockout Cell Lines offer an essential resource for advancing knowledge and innovating new therapeutic approaches. Leveraging years of expertise in genetic engineering and cellular modeling, our company is committed to providing high-quality biological products that empower the scientific community to drive discoveries in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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