Gene: TAB3
Official Full Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by HGNC
Gene Summary: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10983 | TAB3 Knockout cell line (HeLa) | Human | TAB3 | 1:3~1:6 | Negative | Online Inquiry |
KO10984 | TAB3 Knockout cell line (HCT 116) | Human | TAB3 | 1:2~1:4 | Negative | Online Inquiry |
KO10985 | TAB3 Knockout cell line (HEK293) | Human | TAB3 | 1:3~1:6 | Negative | Online Inquiry |
KO10986 | TAB3 Knockout cell line (A549) | Human | TAB3 | 1:3~1:4 | Negative | Online Inquiry |
TAB3 Gene Knockout Cell Lines are genetically engineered cell lines specifically modified to lack functional TAB3 genes. These cell lines serve as crucial tools for researchers investigating the biological roles of the TAB3 gene in signal transduction, immune response, and disease susceptibility. By utilizing CRISPR-Cas9 technology, the TAB3 Gene Knockout Cell Lines allow for precise and efficient knockout of the TAB3 gene, providing a robust platform for studying the gene’s function in various cellular processes.
The primary function of these cell lines is to facilitate detailed analysis of the consequences of TAB3 gene elimination on cellular signaling pathways, especially those involving NF-κB and MAPK pathways. By knocking out the TAB3 gene, researchers can observe the resultant phenotypic changes, alterations in cellular behavior, and gene expression profiles, thereby elucidating the gene's role in modulating immune responses and participating in inflammation-related diseases.
Scientifically, these cell lines hold significant importance in basic research and clinical settings, particularly in developing targeted therapies for diseases like cancer and autoimmune disorders where TAB3 is implicated. The ability to manipulate a gene of interest with outcome predictability enables researchers to model diseases more accurately, driving forward the understanding of pathophysiological mechanisms.
What sets TAB3 Gene Knockout Cell Lines apart from other gene knockout systems is their high efficiency and reliability, alongside an extensive validation process ensuring minimal off-target effects. This reliability makes them an ideal choice for researchers who demand precision in their experimental outcomes. Furthermore, the availability of these knockout lines fosters reproducibility and consistency across studies, greatly enhancing the validity of research findings.
For researchers and clinicians focused on uncovering the complexities of gene function and developing novel therapeutic interventions, TAB3 Gene Knockout Cell Lines offer an invaluable resource that combines innovation with scientific rigor. Our company specializes in the production and development of high-quality biological products backed by extensive expertise in genetics and molecular biology, ensuring that you receive the very best tools for your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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