Gene: SYNCRIP
Official Full Name: synaptotagmin binding cytoplasmic RNA interacting proteinprovided by HGNC
Gene Summary: This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05154 | SYNCRIP Knockout cell line (HeLa) | Human | SYNCRIP | 1:3~1:6 | Negative | Online Inquiry |
KO05155 | SYNCRIP Knockout cell line (HCT 116) | Human | SYNCRIP | 1:2~1:4 | Negative | Online Inquiry |
KO05156 | SYNCRIP Knockout cell line (HEK293) | Human | SYNCRIP | 1:3~1:6 | Negative | Online Inquiry |
KO05157 | SYNCRIP Knockout cell line (A549) | Human | SYNCRIP | 1:3~1:4 | Negative | Online Inquiry |
SYNCRIP Gene Knockout Cell Lines are a specialized range of genetically engineered cell lines designed for the targeted disruption of the SYNCRIP gene, which encodes a protein involved in various cellular processes, including RNA binding, regulation of gene expression, and cellular signaling pathways. These cell lines are developed using advanced CRISPR-Cas9 technology, allowing for precise gene editing and the creation of knockout cells that lack SYNCRIP function.
The primary mechanism of action involves a guide RNA that directs the Cas9 nuclease to the SYNCRIP locus, where it introduces double-strand breaks leading to genomic modifications. This allows researchers to study the biological role of the SYNCRIP gene in different contexts, including its impact on cellular mechanisms such as mRNA splicing, stability, and transport, as well as its implications in disease models.
The scientific importance of SYNCRIP Gene Knockout Cell Lines lies in their application within molecular biology and genetics research. They serve as valuable tools for investigating gene function, elucidating signaling pathways, and model systems for studying diseases such as cancer and neurodegenerative disorders where SYNCRIP is implicated.
Compared to alternative gene-editing approaches, SYNCRIP Gene Knockout Cell Lines offer enhanced specificity and fewer off-target effects, providing researchers with a reliable and efficient method to manipulate gene expression. Additionally, these cell lines are readily available and can be used in diverse experimental setups, streamlining the research process.
For researchers and clinicians, the value of using SYNCRIP Gene Knockout Cell Lines extends beyond basic research; they can assist in drug development, understanding disease mechanisms, and potentially guiding therapeutic interventions. Our company is dedicated to delivering high-quality biological products and understands the critical needs of the scientific community. We pride ourselves on our expertise in gene editing technologies, ensuring that our offerings are not only innovative but reliable for cutting-edge research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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