Gene: SYN2
Official Full Name: synapsin IIprovided by HGNC
Gene Summary: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35154 | SYN2 Knockout cell line (HCT 116) | Human | SYN2 | 1:2~1:4 | Negative | Online Inquiry |
KO35155 | SYN2 Knockout cell line (HEK293) | Human | SYN2 | 1:3~1:6 | Negative | Online Inquiry |
SYN2 Gene Knockout Cell Lines are chemically engineered cellular models designed to facilitate the study of SYN2 gene function and its implications in various biological processes and disease mechanisms. By employing targeted gene editing technologies such as CRISPR-Cas9, these cell lines are generated by disrupting the SYN2 gene, allowing researchers to investigate the resulting phenotypical changes in cellular behavior and physiology.
The primary mechanism of action relies on the complete knockout of the SYN2 gene, leading to the alteration of neurotransmitter release and synaptic functions, which are essential in understanding neurodevelopmental and neurodegenerative disorders. The gene knockout approach provides researchers with a powerful tool for elucidating the roles of SYN2 in neuronal connectivity and signal transduction pathways. By studying these modified cells, scientists can gather vital insights into neurological diseases such as schizophrenia, autism spectrum disorders, and Alzheimer's disease.
The scientific importance of SYN2 Gene Knockout Cell Lines extends to both academic and clinical research settings, where they can be utilized in drug discovery, genetic pathway elucidation, and biomarker development. Compared to traditional approaches or other genetic models, these cell lines offer precise manipulation of the SYN2 gene, resulting in reproducible and robust experimental outcomes.
One of the unique advantages of the SYN2 Gene Knockout Cell Lines is their applicability across diverse experimental paradigms—enabling researchers to explore aspects of cellular signaling, interactions, and potential therapeutic interventions with high fidelity. Additionally, their ease of culture and reproducibility save valuable time and resources in research workflows, making them an indispensable asset.
In summary, the SYN2 Gene Knockout Cell Lines represent a cutting-edge tool for scientists and clinicians seeking to enhance their understanding of complex biological systems. With a commitment to innovation and excellence, our company specializes in supplying high-quality biological products and cell lines that empower the scientific community to push the boundaries of research and advance therapeutic solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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