Home / STX1B Knockout Cell Lines

STX1B Knockout Cell Lines

Gene: STX1B

Official Full Name: syntaxin 1Bprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30913 STX1B Knockout cell line (A549) Human STX1B 1:3~1:4 Negative Online Inquiry

Background

STX1B Gene Knockout Cell Lines are specialized cellular models designed for the study of STX1B (Syntaxin 1B), a gene that plays a crucial role in the regulation of neurotransmitter release in neuronal cells. These knockout cell lines are created through advanced CRISPR-Cas9 gene editing technology, effectively inactivating the STX1B gene and allowing researchers to investigate its specific functions and associated pathways in a controlled environment.

The primary function of STX1B is to facilitate synaptic vesicle docking and fusion at the presynaptic membrane, an essential process for neuronal communication. By utilizing STX1B knockout cell lines, researchers can elucidate the molecular mechanisms underlying synaptic transmission, study the effects of STX1B deficiency on synaptic plasticity, and explore the pathways implicated in neurodevelopmental disorders and neurodegenerative diseases.

The scientific importance of these cell lines is profound, as they provide insights into disorders such as epilepsy, autism spectrum disorders, and other neurodegenerative conditions where dysregulation of neurotransmitter release is implicated. In clinical settings, understanding the role of STX1B can aid in the development of targeted therapies that restore synaptic function.

Compared to alternative models, the STX1B Gene Knockout Cell Lines offer unparalleled specificity and reliability in studying STX1B function. They eliminate the variability seen in genetic heterogeneity in traditional knockout animal models while allowing for high-throughput screening of pharmacological agents and genetic modifiers.

For researchers and clinicians, the ability to manipulate the genetic profile of these cell lines enhances the precision of experimental outcomes, accelerating the journey from fundamental research to potential clinical applications. The value of these knockout cell lines lies in their capability to bridge laboratory findings with therapeutic advancements.

Our company is dedicated to providing high-quality biological products that empower scientists and clinicians to push the boundaries of discovery. With our extensive expertise in gene editing technologies and a commitment to excellence, we ensure that our STX1B Gene Knockout Cell Lines meet the rigorous standards required for impactful research and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.