Gene: STS
Official Full Name: steroid sulfataseprovided by HGNC
Gene Summary: This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38908 | STS Knockout cell line (HeLa) | Human | STS | 1:3~1:6 | Negative | Online Inquiry |
KO38909 | STS Knockout cell line (HEK293) | Human | STS | 1:3~1:6 | Negative | Online Inquiry |
KO38910 | STS Knockout cell line (A549) | Human | STS | 1:3~1:4 | Negative | Online Inquiry |
STS Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functional consequences of targeted gene disruptions. These cell lines are derived from various human and animal sources, providing researchers with the flexibility to select models that best suit their experimental needs. The knockout process involves the precise deletion or modification of specific gene sequences using advanced genome editing technologies, such as CRISPR-Cas9, which allows for high specificity and efficiency in gene targeting.
The primary function of STS Gene Knockout Cell Lines is to enable the investigation of gene function, its role in disease pathways, and the effectiveness of therapeutic interventions. By eliminating the expression of specific genes, researchers can observe resultant phenotypic changes, alterations in cellular signaling pathways, or shifts in metabolic activity, thereby elucidating the gene's contribution to various biological processes. This capability is particularly important in fields such as cancer research, genetics, and pharmacology, where understanding gene functions can lead to the identification of novel therapeutic targets.
Scientifically, STS Gene Knockout Cell Lines play a crucial role in advancing our comprehension of genetic diseases and developing targeted treatments. Their applications span from basic biological research to clinical settings, where they can be utilized to test the effects of drugs on specific genetic conditions or to model various disease phenotypes. This makes them invaluable tools for researchers aiming to translate findings from bench to bedside.
When compared to other gene editing strategies or cellular models, STS Gene Knockout Cell Lines offer unique advantages. They provide a consistent and reproducible platform for experiments, and their genetically modified nature allows for a clear understanding of gene function without confounding effects from other genetic variations. Additionally, the availability of a range of knockout lines across multiple genetic backgrounds enables personalized and diverse approaches to research.
For researchers and clinicians, the value of STS Gene Knockout Cell Lines lies in their ability to drive innovation and enhance the understanding of gene functions in health and disease. These cell lines empower users to design experiments that can lead to breakthroughs in therapy development, enhancing the efficacy and precision of medical advancements.
At our company, we specialize in providing high-quality biological products and advanced genetic tools, ensuring that researchers have access to the most reliable and cutting-edge resources in the field. Our expertise in cell line engineering fortifies our commitment to supporting scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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