Gene: STK26
Official Full Name: serine/threonine kinase 26provided by HGNC
Gene Summary: The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22212 | STK26 Knockout cell line (HeLa) | Human | STK26 | 1:3~1:6 | Negative | Online Inquiry |
KO22213 | STK26 Knockout cell line (HCT 116) | Human | STK26 | 1:2~1:4 | Negative | Online Inquiry |
KO22214 | STK26 Knockout cell line (HEK293) | Human | STK26 | 1:3~1:6 | Negative | Online Inquiry |
KO22215 | STK26 Knockout cell line (A549) | Human | STK26 | 1:3~1:4 | Negative | Online Inquiry |
STK26 Gene Knockout Cell Lines are specifically engineered cellular models in which the STK26 gene has been precisely deleted or inactivated. The STK26 gene, encoding a serine/threonine kinase, plays a pivotal role in various cellular processes, including controlling cellular growth, stress responses, and apoptosis. By utilizing CRISPR/Cas9 or other gene-editing techniques, these knockout cell lines facilitate comprehensive studies on the functions of the STK26 protein and its contributions to signaling pathways.
The primary mechanism of action involves the disruption of the STK26 gene, allowing researchers to observe the resulting phenotypic changes. This provides critical insights into the gene's role in cellular mechanisms and disease states, especially in contexts such as cancer and neurodegenerative disorders, where STK26 may influence crucial pathways. In research and clinical settings, these cell lines are invaluable for elucidating the molecular basis of diseases, testing drug efficacy, and understanding cellular responses to stress or injury.
Compared to alternative models, STK26 Gene Knockout Cell Lines offer unique advantages including precise gene editing, reproducibility, and the ability to study the effects of complete gene ablation in a controlled environment. These features ensure higher specificity in experimental outcomes, reducing off-target effects that may confound results obtained from pharmacological approaches or traditional RNA interference.
For researchers and clinicians alike, the utility of these knockout models lies in their ability to shed light on complex biological processes, supporting the development of targeted therapeutic strategies. They serve as an essential tool for advancing our understanding of gene function and its implications in health and disease.
Our company specializes in the development of high-quality biological products, armed with a team of experts committed to providing innovative research solutions. With a focus on precision and reliability, we offer a range of cell lines and genetic models tailored for the modern scientific landscape, positioning our customers at the forefront of biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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