Gene: STARD4
Official Full Name: StAR related lipid transfer domain containing 4provided by HGNC
Gene Summary: Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26442 | STARD4 Knockout cell line (HeLa) | Human | STARD4 | 1:3~1:6 | Negative | Online Inquiry |
KO26443 | STARD4 Knockout cell line (HCT 116) | Human | STARD4 | 1:2~1:4 | Negative | Online Inquiry |
KO26444 | STARD4 Knockout cell line (HEK293) | Human | STARD4 | 1:3~1:6 | Negative | Online Inquiry |
KO26445 | STARD4 Knockout cell line (A549) | Human | STARD4 | 1:3~1:4 | Negative | Online Inquiry |
STARD4 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene modification to disrupt the function of the STARD4 gene, which encodes a protein implicated in lipid metabolism and cellular signaling pathways. These knockout cell lines serve as invaluable tools for researchers investigating the biological roles of STARD4, particularly its contributions to lipid storage, transport, and the cellular response to various metabolic signals.
The primary function of STARD4 is to facilitate the transport of lipids, particularly cholesterol, between cellular compartments, thereby influencing membrane composition and signaling pathways. In these knockout lines, the absence of STARD4 allows for the functional dissection of lipid metabolism and signaling mechanisms, enabling researchers to examine the consequences of STARD4 loss on various cellular processes such as proliferation, apoptosis, and differentiation. The perturbation of these pathways can provide insights into the etiology of metabolic disorders and other conditions where lipid metabolism is dysregulated.
The scientific importance of STARD4 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In research settings, they enable the exploration of new therapeutic targets for diseases such as obesity, diabetes, and cardiovascular disorders. Clinically, understanding the role of STARD4 can lead to innovative treatment strategies that leverage lipid metabolism for therapeutic gain, making these cell lines crucial in drug discovery and development initiatives.
Compared to alternative models, STARD4 Gene Knockout Cell Lines offer specific advantages, including the ability to study the effects of gene loss in a controlled environment that mimics native cellular conditions. This specificity provides a higher degree of relevance to investigations concerning human health and disease mechanisms. Additionally, these cell lines are rigorously validated to ensure integrity and reproducibility, significantly enhancing the reliability of experimental outcomes.
For researchers and clinicians, the STARD4 Gene Knockout Cell Lines represent a cutting-edge resource that expands the potential for breakthroughs in understanding and treating metabolic disorders. The promise of discovering novel therapeutic strategies and shedding light on cellular mechanisms tied to STARD4 are compelling reasons to incorporate this tool into one's research or clinical framework.
At [Company Name], we are committed to advancing scientific knowledge through high-quality biological products. Our expertise in genetic engineering and commitment to rigorous quality standards ensures that our STARD4 Gene Knockout Cell Lines are among the best available, empowering researchers and clinicians to achieve their scientific objectives with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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