Gene: SSR3
Official Full Name: signal sequence receptor subunit 3provided by HGNC
Gene Summary: The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35227 | SSR3 Knockout cell line (HeLa) | Human | SSR3 | 1:3~1:6 | Negative | Online Inquiry |
KO35228 | SSR3 Knockout cell line (HCT 116) | Human | SSR3 | 1:2~1:4 | Negative | Online Inquiry |
KO35229 | SSR3 Knockout cell line (HEK293) | Human | SSR3 | 1:3~1:6 | Negative | Online Inquiry |
KO35230 | SSR3 Knockout cell line (A549) | Human | SSR3 | 1:3~1:4 | Negative | Online Inquiry |
SSR3 Gene Knockout Cell Lines are meticulously engineered cellular models designed to study the function of the SSR3 gene, which encodes a protein involved in crucial cellular processes such as protein translocation, endoplasmic reticulum (ER) stress response, and glycoprotein synthesis. By utilizing CRISPR/Cas9 technology, these cell lines facilitate precise gene editing, resulting in the targeted deletion of the SSR3 gene, allowing researchers to investigate the downstream effects of SSR3 loss-of-function in various biological pathways.
The key mechanism underlying the efficacy of SSR3 Gene Knockout Cell Lines lies in their ability to provide insights into the role of SSR3 in ER function and protein maturation. This has implications in understanding diseases associated with ER stress, including certain cancers and metabolic disorders. By cultivating these cells, researchers can assess alterations in cell proliferation, apoptosis, and stress signaling pathways, thus gaining valuable insights into therapeutic targets and biological mechanisms.
In terms of scientific importance, SSR3 Gene Knockout Cell Lines serve as an indispensable resource for both academic research and pharmaceutical applications. These cell lines enable the screening of drug candidates aimed at modulating ER stress and evaluating potential therapeutic strategies in ER-related diseases. Compared to conventional methods such as RNA interference, the knockout model provides a more stable and permanent alteration of gene function, resulting in highly reproducible and clear biological outcomes.
What sets SSR3 Gene Knockout Cell Lines apart from competitors is their robust characterization and validation protocols, ensuring consistency and reliability for researchers. Furthermore, the availability of accompanying comprehensive user support and resources enhances the research experience, making it easier for scientists to translate findings into impactful applications.
For researchers and clinicians seeking to deepen their understanding of the molecular underpinnings of various disease states, SSR3 Gene Knockout Cell Lines represent a valuable tool. With proven expertise in cellular biology and gene editing technologies, our company is committed to offering high-quality biological products that empower the scientific community in their quest for knowledge and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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