Gene: SSH1
Official Full Name: slingshot protein phosphatase 1provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21776 | SSH1 Knockout cell line (HeLa) | Human | SSH1 | 1:3~1:6 | Negative | Online Inquiry |
KO21777 | SSH1 Knockout cell line (HCT 116) | Human | SSH1 | 1:2~1:4 | Negative | Online Inquiry |
KO21778 | SSH1 Knockout cell line (HEK293) | Human | SSH1 | 1:3~1:6 | Negative | Online Inquiry |
KO21779 | SSH1 Knockout cell line (A549) | Human | SSH1 | 1:3~1:4 | Negative | Online Inquiry |
SSH1 Gene Knockout Cell Lines are engineered cell lines in which the SSH1 gene, known for its roles in cell signaling and cytoskeletal dynamics, has been effectively disrupted through targeted genetic modification techniques. SSH1, or Slingshot Protein Phosphatase 1, regulates actin filament dynamics by dephosphorylating proteins that are critical for cellular movement and growth. The knockout of this gene allows researchers to investigate the specific contributions of SSH1 to various biological processes, particularly in cancer metastasis and neurodegenerative diseases.
The functionality of SSH1 Knockout Cell Lines stems from their ability to create a stark contrast in experimental outcomes compared to wild-type cells. Researchers can observe the impacts of SSH1 absence on cellular morphology, motility, proliferation, and signaling pathways. This moderated approach allows for the elucidation of SSH1’s precise role in cellular contexts, providing invaluable insights into its function as a regulator of actin dynamics.
Scientifically, these knockout cell lines serve as a pivotal tool in therapeutic research and drug development. Their applications extend into screening compounds that may restore normal function or mitigate the effects of SSH1 loss, paving the way for novel treatments in oncological and neurobiological contexts.
One of the unique selling points of SSH1 Gene Knockout Cell Lines is their high specificity and reproducibility compared to other gene editing methods, such as CRISPR, which may introduce off-target effects. Each line is meticulously validated to ensure the complete ablation of SSH1 expression, thereby enhancing the reliability of experimental results.
For researchers and clinicians aiming to explore cytoskeletal regulatory mechanisms, these cell lines offer a direct and effective means of investigation, facilitating significant advancements in understanding disease pathology and treatment strategies. Our company prides itself on its deep expertise in genetic engineering and cell line development, providing high-quality biological tools that empower scientific discovery and innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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