Gene: SPRY2
Official Full Name: sprouty RTK signaling antagonist 2provided by HGNC
Gene Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32063 | SPRY2 Knockout cell line (HeLa) | Human | SPRY2 | 1:3~1:6 | Negative | Online Inquiry |
KO32064 | SPRY2 Knockout cell line (HCT 116) | Human | SPRY2 | 1:2~1:4 | Negative | Online Inquiry |
KO32065 | SPRY2 Knockout cell line (HEK293) | Human | SPRY2 | 1:3~1:6 | Negative | Online Inquiry |
KO32066 | SPRY2 Knockout cell line (A549) | Human | SPRY2 | 1:3~1:4 | Negative | Online Inquiry |
SPRY2 Gene Knockout Cell Lines are specialized cellular models designed to study the biological functions of the SPRY2 gene, which is involved in various signaling pathways, including the regulation of cell growth and differentiation. By utilizing CRISPR-Cas9 technology, these cell lines have been engineered to disrupt the SPRY2 gene, providing researchers with a powerful tool to investigate the gene's role in diseases such as cancer and developmental disorders.
The primary mechanism of these knockout cell lines relies on the precise editing of the SPRY2 gene, resulting in the complete ablation of its expression. This allows for the assessment of phenotypic changes in response to SPRY2 loss, such as alterations in cellular proliferation, apoptosis, and migration. Researchers can utilize these cell lines to dissect the molecular pathways influenced by SPRY2, driving forward a deeper understanding of its contributions to tumorigenesis and other pathological conditions.
The scientific importance of SPRY2 Gene Knockout Cell Lines is underscored by their applications in drug discovery and development, enabling the identification of novel therapeutic targets and biomarkers. In clinical research settings, these models facilitate the exploration of SPRY2's involvement in resistance to therapies, thereby informing more effective treatment strategies.
Compared to traditional methods of gene manipulation, such as siRNA or shRNA knockdown, these knockout cell lines offer a more stable and definitive disruption of gene function, yielding clearer insights into gene-specific effects over time. Additionally, they can be easily cultured and expanded, allowing for reproducible experiments under consistent conditions.
For researchers and clinicians, the development of SPRY2 Gene Knockout Cell Lines represents a crucial advancement in the quest to unravel complex biological processes. Their inherent value lies in delivering clear, actionable data that can drive both foundational research and clinical applications. With our company’s deep expertise in gene editing technologies and commitment to quality, we offer these knockout cell lines as part of a comprehensive portfolio aimed at supporting cutting-edge research and innovation in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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