Gene: SPAG1
Official Full Name: sperm associated antigen 1provided by HGNC
Gene Summary: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13834 | SPAG1 Knockout cell line (HeLa) | Human | SPAG1 | 1:3~1:6 | Negative | Online Inquiry |
KO13835 | SPAG1 Knockout cell line (HCT 116) | Human | SPAG1 | 1:2~1:4 | Negative | Online Inquiry |
KO13836 | SPAG1 Knockout cell line (HEK293) | Human | SPAG1 | 1:3~1:6 | Negative | Online Inquiry |
KO13837 | SPAG1 Knockout cell line (A549) | Human | SPAG1 | 1:3~1:4 | Negative | Online Inquiry |
SPAG1 Gene Knockout Cell Lines are essential research tools designed to elucidate the biological functions of the SPAG1 gene, which encodes for a protein associated with sperm motility and development. This product features genetically engineered cell lines where the SPAG1 gene has been disrupted using CRISPR/Cas9 technology, allowing researchers to investigate the consequences of loss-of-function mutations on cellular mechanisms and physiological processes.
The primary function of SPAG1 Gene Knockout Cell Lines lies in their ability to facilitate the dissection of reproductive biology and related signaling pathways. By analyzing these knockout lines, scientists can observe alterations in cell morphology, motility, and viability, providing critical insights into sperm function and fertility. This is particularly valuable in studies aimed at understanding male infertility, as well as the broader implications of motility in various cellular contexts.
In both research and clinical settings, the scientific importance of these cell lines cannot be understated. They serve as a functional model for disease modeling, drug discovery, and the identification of potential therapeutic targets. Moreover, these knockout cell lines enable high-throughput screening of pharmacological agents, aiding in the development of new fertility treatments or interventions targeting related conditions.
One of the unique selling points of SPAG1 Gene Knockout Cell Lines is their precision and specificity. Compared to alternative methods, such as RNA interference or traditional knockout techniques, CRISPR/Cas9 offers a more effective, efficient, and reliable approach to gene editing, resulting in stable and reproducible models. Researchers can also benefit from the ability to generate multiple knockout clones, thereby enhancing the robustness of their experimental outcomes.
These cell lines are invaluable to researchers and clinicians focused on reproductive health, cellular dynamics, and related fields, as they provide a cutting-edge platform for advanced investigations into gene function and disease urgency. Furthermore, our company has a long-standing commitment to excellence in genetic model development, backed by extensive expertise in molecular biology, ensuring that our products meet the highest standards in scientific research.
Please note that all services are for research use only. Not intended for any clinical use.
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