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SOX8 Knockout Cell Lines

Gene: SOX8

Official Full Name: SRY-box transcription factor 8provided by HGNC

Gene Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26757 SOX8 Knockout cell line (HCT 116) Human SOX8 1:2~1:4 Negative Online Inquiry
KO26758 SOX8 Knockout cell line (HEK293) Human SOX8 1:3~1:6 Negative Online Inquiry

Background

The SOX8 Gene Knockout Cell Lines are specialized cellular models that have been engineered to contain a complete deletion of the SOX8 gene, a pivotal transcription factor associated with various developmental processes and cellular functions. By removing this gene, the cell lines allow researchers to study the role of SOX8 in gene regulation, cell differentiation, and disease pathology without the influence of its protein product. These knockout models provide a crucial tool for elucidating the biological pathways that SOX8 influences and contribute to a deeper understanding of cell biology.

The primary mechanism of action involves the targeted disruption of the SOX8 gene using CRISPR-Cas9 technology, ensuring a precise edit that allows for straightforward validation of gene function. Researchers can utilize these cell lines to assess the phenotypic consequences of the absence of SOX8, including changes in cellular morphology, proliferation rates, and differentiation potential. Such analyses are particularly valuable for studies related to embryonic development, stem cell biology, and oncogenesis, as dysregulation of transcription factors like SOX8 can lead to significant clinical implications.

The scientific importance of SOX8 Gene Knockout Cell Lines extends into diverse fields, including developmental biology, cancer research, and regenerative medicine. Their ability to serve as models for specific genetic conditions allows for high-throughput screening of therapeutic agents and the validation of gene-targeted therapies.

Compared to other gene knockout models, these cell lines offer superior specificity and reproducibility due to the precise design and validation processes employed in their creation. Users can expect consistent performance across multiple experiments, which is essential for reliable data generation and interpretation.

For researchers and clinicians alike, these cell lines represent a valuable resource not only for basic research into transcriptional regulation but also for the development of targeted therapeutic strategies. By understanding the function of the SOX8 gene, life scientists can pave the way for innovative treatment options for diseases linked to its dysregulation.

With a commitment to quality and innovation, our company brings extensive expertise in producing high-fidelity biological products, ensuring that our SOX8 Gene Knockout Cell Lines meet the stringent requirements of modern scientific research. Our dedication to advancing biological understanding makes us your trusted partner in the quest for scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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