Gene: SNX27
Official Full Name: sorting nexin 27provided by HGNC
Gene Summary: This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25706 | SNX27 Knockout cell line (HeLa) | Human | SNX27 | 1:3~1:6 | Negative | Online Inquiry |
KO25707 | SNX27 Knockout cell line (HCT 116) | Human | SNX27 | 1:2~1:4 | Negative | Online Inquiry |
KO25708 | SNX27 Knockout cell line (HEK293) | Human | SNX27 | 1:3~1:6 | Negative | Online Inquiry |
KO25709 | SNX27 Knockout cell line (A549) | Human | SNX27 | 1:3~1:4 | Negative | Online Inquiry |
SNX27 Gene Knockout Cell Lines are a meticulously developed biological tool designed to facilitate the study of SNX27 (Sorting Nexin 27), a protein implicated in diverse cellular processes, including receptor trafficking and signal transduction. These genetically modified cell lines enable researchers to investigate the specific contributions of SNX27 to cellular homeostasis and its potential role in pathogenic processes, including cancer and neurodegenerative diseases.
The key function of SNX27 Gene Knockout Cell Lines is to eliminate the expression of the SNX27 protein, creating a model that lacks the normal regulatory mechanisms associated with this protein. By doing so, researchers can elucidate the downstream effects on various biochemical pathways, providing insights into how disruptions in SNX27 can influence cellular communication and function. The mechanism underlying this knockout is based on CRISPR/Cas9 technology, enabling precise gene editing and ensuring the fidelity of the resulting genetic modification.
The scientific importance of these cell lines lies in their applicability in both research and clinical settings. They serve as a vital resource for studies focusing on receptor signaling pathways, drug response mechanisms, and the molecular underpinnings of diseases where SNX27 is a significant player. Additionally, these models are indispensable for validating potential therapeutic targets and assessing the efficacy of novel compounds.
When compared to other available genetic models, SNX27 Gene Knockout Cell Lines offer distinct advantages, including high specificity, consistent performance, and the ability to be used across various cell types. Furthermore, the loss of SNX27 can reveal compensatory mechanisms that would otherwise be masked in intact models, thus providing a more holistic understanding of cellular dynamics.
For researchers and clinicians, the practical value of these cell lines cannot be overstated. They enable advanced exploration of the functional roles that SNX27 plays, ultimately leading to findings that could facilitate new therapeutic strategies and improve patient outcomes.
Our company, with extensive experience in the production of high-quality genetic tools, is committed to supporting the scientific community with innovative and reliable products like the SNX27 Gene Knockout Cell Lines, designed for the pursuit of groundbreaking research and meaningful clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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