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SMOX Knockout Cell Lines

Gene: SMOX

Official Full Name: spermine oxidaseprovided by HGNC

Gene Summary: Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21687 SMOX Knockout cell line (HeLa) Human SMOX 1:3~1:6 Negative Online Inquiry
KO21688 SMOX Knockout cell line (HCT 116) Human SMOX 1:2~1:4 Negative Online Inquiry
KO21689 SMOX Knockout cell line (HEK293) Human SMOX 1:3~1:6 Negative Online Inquiry
KO21690 SMOX Knockout cell line (A549) Human SMOX 1:3~1:4 Negative Online Inquiry

Background

SMOX Gene Knockout Cell Lines are specialized, genetically engineered cell lines in which the SMOX (Spermine Oxidase) gene has been inactivated, offering researchers a powerful tool for studying the role of polyamine metabolism in various biological processes. This knockout model allows for detailed investigation into the physiological implications of reduced SMOX activity, particularly in the context of cellular oxidative stress, apoptosis, and inflammation.

The primary mechanism of action in these cell lines involves the disruption of spermine oxidation, thereby diminishing the production of reactive oxygen species (ROS) associated with SMOX activity. By utilizing these cell lines, researchers can elucidate the contribution of SMOX to numerous pathophysiological conditions, including cancer, cardiovascular diseases, and neurodegenerative disorders. This precise manipulation of gene function enables a deeper understanding of disease mechanisms and potential therapeutic targets, shaping the future of molecular biology research.

In comparison to other gene knockout models, SMOX Gene Knockout Cell Lines provide specific advantages, such as a well-characterized background and optimized growth conditions, allowing for consistent experimental outcomes. Moreover, the availability of these lines fosters comparative studies, enabling scientists to elucidate differences in gene expression and metabolic pathways more readily.

This product represents an invaluable resource for researchers seeking to explore the intricacies of polyamine biology in both fundamental and applied settings. By integrating SMOX Gene Knockout Cell Lines into their work, clinicians and academic researchers alike can advance the understanding of related diseases, informing novel therapeutic strategies and interventions.

Our company prides itself on a robust background in genetic engineering and cell line development, ensuring that our products meet the highest standards of quality and reliability in research applications. With a commitment to innovation, we continue to provide cutting-edge solutions tailored to the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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