Gene: SLX4
Official Full Name: SLX4 structure-specific endonuclease subunitprovided by HGNC
Gene Summary: This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00311 | SLX4 gRNA1-gRNA2 KO plasmid | SLX4 | $850 | |||
GP00346 | SLX4 gRNA3-gRNA4 KO plasmid | SLX4 | $850 | |||
KO06427 | SLX4 Knockout cell line (HeLa) | Human | SLX4 | 1:3~1:6 | Negative | Online Inquiry |
KO06428 | SLX4 Knockout cell line (HCT 116) | Human | SLX4 | 1:2~1:4 | Negative | Online Inquiry |
KO06429 | SLX4 Knockout cell line (HEK293) | Human | SLX4 | 1:3~1:6 | Negative | Online Inquiry |
KO06430 | SLX4 Knockout cell line (A549) | Human | SLX4 | 1:3~1:4 | Negative | Online Inquiry |
SLX4 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the role of the SLX4 gene in various biological processes, particularly those related to DNA damage response and repair mechanisms. These cell lines have undergone precise genetic alterations to disrupt the SLX4 gene, allowing researchers to investigate the resulting phenotypic changes, elucidate pathways of genomic integrity, and explore implications for diseases such as cancer.
The primary mechanism of SLX4 involves its function as a scaffold protein that coordinates multiple nucleases and helicases, playing a crucial role in the resolution of DNA structures formed during replication stress and interstrand cross-link repair. By utilizing these knockout cell lines, scientists can dissect the cellular phenotypes that arise from SLX4 deficiency, providing insights into the pathways that maintain genomic stability.
The scientific importance of SLX4 Gene Knockout Cell Lines is evident in both research and clinical applications. They serve as vital tools for elucidating the molecular underpinnings of therapeutic resistance in oncology, making them integral for developing targeted therapies. Additionally, they can facilitate the study of hereditary repair disorders, offering a clearer understanding of pathogenic mechanisms.
Compared to alternative models, our SLX4 Gene Knockout Cell Lines offer distinct advantages including a high efficiency in gene editing, robust reproducibility, and a comprehensive analytical approach. These features ensure that researchers can obtain reliable and consistent results when investigating DNA repair pathways or developing novel therapeutic strategies.
For researchers and clinicians focused on molecular genetics, oncology, or cellular biology, the SLX4 Gene Knockout Cell Lines represent an invaluable resource, equipping them with the tools necessary to drive innovation in understanding disease mechanisms and enhancing treatment modalities. At [Your Company Name], we pride ourselves on offering cutting-edge cellular models that push the boundaries of scientific discovery, backed by our team of experienced professionals dedicated to supporting your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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