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SLC35D1 Knockout Cell Lines

Gene: SLC35D1

Official Full Name: solute carrier family 35 member D1provided by HGNC

Gene Summary: Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia.[provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29741 SLC35D1 Knockout cell line (HeLa) Human SLC35D1 1:3~1:6 Negative Online Inquiry
KO29742 SLC35D1 Knockout cell line (HCT 116) Human SLC35D1 1:2~1:4 Negative Online Inquiry
KO29743 SLC35D1 Knockout cell line (HEK293) Human SLC35D1 1:3~1:6 Negative Online Inquiry
KO29744 SLC35D1 Knockout cell line (A549) Human SLC35D1 1:3~1:4 Negative Online Inquiry

Background

SLC35D1 Gene Knockout Cell Lines are invaluable models designed to study the functions of the SLC35D1 gene, which is known to play a pivotal role in nucleotide sugar transport and cellular glycosylation processes. These cell lines are genetically engineered to lack the SLC35D1 gene, enabling researchers to dissect the gene's impact on various biological pathways and its contributions to health and disease states.

The knockout mechanism creates a loss-of-function model whereby the absence of SLC35D1 allows for the observation of altered cellular behaviors, including changes in glycosylation patterns, which can affect protein stability, signaling, and cell-cell interactions. By utilizing these specific cell lines, researchers can investigate the downstream effects of SLC35D1 deficiency, offering insights into potential disease mechanisms, particularly in cancer and metabolic disorders.

Scientifically, the importance of SLC35D1 Gene Knockout Cell Lines extends to their application in drug discovery, biomarker identification, and the exploration of therapeutic targets. They provide a robust platform for elucidating how nucleotide sugar transport influences cellular physiology, making them suitable for both basic and applied research in biomedical settings.

Compared to alternative models, our SLC35D1 Gene Knockout Cell Lines offer superior reproducibility and reliability due to our rigorous validation processes. The targeted knockout allows for precise manipulation of this gene without the confounding influences that may arise from less specific methods, such as chemical inhibition or RNA interference.

Researchers and clinicians seeking to understand glycosylation's role in health and disease will find these cell lines indispensable. They are not only supportive of pioneering inquiries but also hold promises for future therapeutic development. Our company specializes in providing high-quality, validated biological products backed by scientific expertise, ensuring that our offerings empower research excellence and clinical advancements in the field.

Please note that all services are for research use only. Not intended for any clinical use.

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