Gene: SLC33A1
Official Full Name: solute carrier family 33 member 1provided by HGNC
Gene Summary: The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33482 | SLC33A1 Knockout cell line (HeLa) | Human | SLC33A1 | 1:3~1:6 | Negative | Online Inquiry |
KO33483 | SLC33A1 Knockout cell line (HCT 116) | Human | SLC33A1 | 1:2~1:4 | Negative | Online Inquiry |
KO33484 | SLC33A1 Knockout cell line (HEK293) | Human | SLC33A1 | 1:3~1:6 | Negative | Online Inquiry |
SLC33A1 Gene Knockout Cell Lines are genetically modified cell lines in which the SLC33A1 gene has been intentionally disrupted or "knocked out." This gene encodes for a key transporter protein involved in the uptake of neurotransmitters and metabolites, playing a significant role in cellular homeostasis and communication. By utilizing these knockout cell lines, researchers can readily investigate the specific biological functions and pathways associated with SLC33A1, thereby elucidating its role in various physiological and pathological contexts.
The primary function of SLC33A1 is to mediate the transport of essential molecules across cellular membranes. In the absence of this transporter, researchers are able to study compensatory mechanisms and the implications for neurotransmitter signaling, metabolic processes, and overall cellular behaviors. This is particularly crucial in fields such as neurobiology and cancer research, where understanding the nuances of cellular transport can reveal insights into disease mechanisms and therapeutic targets.
The scientific importance of SLC33A1 Knockout Cell Lines is underscored by their diverse applications. In research settings, these cell lines facilitate the study of metabolic disorders, neurodevelopmental conditions, and drug response mechanisms. Clinically, the insights gleaned from such studies could inform the development of targeted therapies and improve patient outcomes.
A key advantage of our SLC33A1 Gene Knockout Cell Lines is their high reproducibility and reliability, which contrasts with alternative models that may show variability due to incomplete knockout or off-target effects. Additionally, these cell lines are derived from well-characterized backgrounds, providing a consistent platform for experimental work.
For researchers and clinicians alike, the value of SLC33A1 Knockout Cell Lines lies in their ability to provide a clearer understanding of this critical gene's role in health and disease. By incorporating these cell lines into research protocols, users are equipped with the tools necessary to advance their studies in a meaningful way.
Our company specializes in providing high-quality biological research products, backed by extensive expertise in genetic engineering and cell line development. We are committed to delivering innovative solutions to empower scientific discovery and therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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