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SLC27A5 Knockout Cell Lines

Gene: SLC27A5

Official Full Name: solute carrier family 27 member 5provided by HGNC

Gene Summary: The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31344 SLC27A5 Knockout cell line (HeLa) Human SLC27A5 1:3~1:6 Negative Online Inquiry
KO31345 SLC27A5 Knockout cell line (HCT 116) Human SLC27A5 1:2~1:4 Negative Online Inquiry
KO31346 SLC27A5 Knockout cell line (HEK293) Human SLC27A5 1:3~1:6 Negative Online Inquiry
KO31347 SLC27A5 Knockout cell line (A549) Human SLC27A5 1:3~1:4 Negative Online Inquiry

Background

SLC27A5 Gene Knockout Cell Lines are specifically engineered cell lines in which the SLC27A5 gene has been disrupted through targeted gene editing techniques such as CRISPR/Cas9. This crucial gene encodes for the fatty acid transporter protein, which plays a significant role in cellular lipid metabolism. By creating knockout models, researchers can eliminate the expression of SLC27A5, enabling the study of its functional contributions to fatty acid uptake, metabolism, and related pathophysiological processes.

The primary mechanism of action involves the loss of SLC27A5-mediated transport, leading to altered lipid distribution and metabolism that researchers can exploit to investigate the role of lipids in cellular physiology and disease. The availability of these cell lines facilitates comprehensive studies on disorders related to insulin resistance, obesity, and metabolic syndrome, enhancing understanding that can drive therapeutic advancements.

From a scientific standpoint, SLC27A5 Gene Knockout Cell Lines are invaluable in both research and clinical applications. They allow scientists to investigate complex signaling pathways and lipid interactions in various biological contexts, including cancer biology, cardiovascular diseases, and metabolic disorders. Furthermore, such models pave the way for drug discovery efforts targeting lipid metabolism, providing a reliable platform for the screening of pharmacological agents.

What sets SLC27A5 Gene Knockout Cell Lines apart from existing alternatives is their high specificity and accuracy in genetic disruption, which leads to more reproducible and robust experimental outcomes. Unlike transient knockdown approaches, these stable knockout lines ensure long-term studies without the variability that can complicate interpretations.

The value of this product lies in its capacity to empower researchers and clinicians alike, allowing for deeper insights into lipid-related diseases and accelerating the development of new therapeutic strategies. Our company specializes in providing high-quality genetic models and supports their applications through extensive technical expertise and customer service, ensuring that scientists maximize the potential of their research initiatives.

Please note that all services are for research use only. Not intended for any clinical use.

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