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SLC16A8 Knockout Cell Lines

Gene: SLC16A8

Official Full Name: solute carrier family 16 member 8provided by HGNC

Gene Summary: SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29176 SLC16A8 Knockout cell line (HCT 116) Human SLC16A8 1:2~1:4 Negative Online Inquiry
KO29177 SLC16A8 Knockout cell line (HEK293) Human SLC16A8 1:3~1:6 Negative Online Inquiry

Background

SLC16A8 Gene Knockout Cell Lines are engineered cell lines specifically designed to lack the expression of the SLC16A8 gene, a key player in the transport of monocarboxylates such as lactate and pyruvate across the cell membrane. This knockout facilitates in-depth studies into the physiological and pathological roles of SLC16A8, providing insights into metabolic processes and cellular signaling pathways that are crucial for both normal cellular function and disease states.

The fundamental mechanism employed in creating these cell lines involves precise gene editing techniques, such as CRISPR/Cas9. This results in the disruption of the SLC16A8 gene, enabling researchers to observe the consequences of its absence on cellular metabolism and communication. Consequently, this can yield critical data on the role of monocarboxylate transporters in cancer metabolism, neurodegenerative diseases, and regulatory processes regarding energy homeostasis.

The scientific importance of SLC16A8 Gene Knockout Cell Lines extends to various research and clinical applications. They serve as vital tools for elucidating metabolic pathways and the effects of metabolic dysregulation on cellular behavior. These cell lines are invaluable in drug discovery efforts aimed at targeting metabolic diseases, including cancer, where altered monocarboxylate transport is often observed. Additionally, they hold potential in studying the contributions of metabolic interactions in neurobiology.

Compared to alternative models, SLC16A8 Gene Knockout Cell Lines offer unmatched specificity and consistency in experimental outcomes, as they are precisely altered to study the gene of interest. By utilizing these specialized lines, researchers can achieve higher accuracy and reproducibility in their studies, ultimately accelerating the pace of discovery related to metabolic function and disease.

For researchers, clinicians, and biopharmaceutical companies alike, SLC16A8 Gene Knockout Cell Lines are a valuable addition to the toolkit needed to dissect complex biological systems. Their ability to provide targeted insights into gene function and metabolic profiling helps bridge the gap between fundamental biology and clinical application. Our company excels in developing high-quality biological products, backed by rigorous scientific validation and expertise, ensuring our clientele receives innovative solutions to advance their research goals.

Please note that all services are for research use only. Not intended for any clinical use.

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