Gene: SIPA1L3
Official Full Name: signal induced proliferation associated 1 like 3provided by HGNC
Gene Summary: This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08724 | SIPA1L3 Knockout cell line (HeLa) | Human | SIPA1L3 | 1:3~1:6 | Negative | Online Inquiry |
KO08725 | SIPA1L3 Knockout cell line (HCT 116) | Human | SIPA1L3 | 1:2~1:4 | Negative | Online Inquiry |
KO08726 | SIPA1L3 Knockout cell line (HEK293) | Human | SIPA1L3 | 1:3~1:6 | Negative | Online Inquiry |
KO08727 | SIPA1L3 Knockout cell line (A549) | Human | SIPA1L3 | 1:3~1:4 | Negative | Online Inquiry |
SIPA1L3 Gene Knockout Cell Lines are genetically modified cellular models specifically engineered to silence the expression of the SIPA1L3 gene, a critical regulator in various cellular signaling pathways. These knockout cell lines utilize CRISPR-Cas9 technology to provide a stable and efficient means of studying gene function and elucidating the molecular mechanisms underlying cellular processes. By creating a loss-of-function scenario for the SIPA1L3 gene, researchers can investigate its role in cell migration, proliferation, and other vital biological functions, shedding light on pathways that may be implicated in diseases such as cancer and neurological disorders.
The primary mechanism of action in SIPA1L3 Gene Knockout Cell Lines is the introduction of targeted double-strand breaks in the genomic DNA. This leads to the disruption of the gene’s coding sequence, resulting in non-functional protein expression. This knockout technique allows for precise modifications, ensuring that researchers can observe the phenotypic consequences of SIPA1L3 loss in a controlled environment. Such models are invaluable for studying gene function in vitro and can be employed to identify potential therapeutic targets.
The scientific importance of SIPA1L3 Gene Knockout Cell Lines extends to both research and clinical applications. These cell lines are pivotal in the development of novel therapeutic strategies or drug screening processes, allowing researchers to uncover critical insights into gene interactions and cell behavior. Compared to traditional gene knockdown methods, such as siRNA or shRNA approaches that can result in incomplete suppression, CRISPR-Cas9 mediated knockout ensures permanent gene inactivation; thus, providing a more robust model for long-term studies.
Researchers and clinicians seeking accurate, reliable data on gene function will find SIPA1L3 Gene Knockout Cell Lines to be indispensable. The value of these cell lines lies in their ability to facilitate high-throughput screening and experimental reproducibility, characteristics that are essential for modern biological research. Additionally, the comprehensive support and expertise provided by our company in gene editing technologies ensure users can effectively leverage these cell lines in their investigations.
With a commitment to advancing research tools, our company specializes in the development of high-quality genetic models that empower scientific discovery and foster innovation in the biological sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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