Gene: SHLD2
Official Full Name: shieldin complex subunit 2provided by HGNC
Gene Summary: Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in actin cytoskeleton; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21636 | SHLD2 Knockout cell line (HeLa) | Human | SHLD2 | 1:3~1:6 | Negative | Online Inquiry |
KO21637 | SHLD2 Knockout cell line (HCT 116) | Human | SHLD2 | 1:2~1:4 | Negative | Online Inquiry |
KO21638 | SHLD2 Knockout cell line (HEK293) | Human | SHLD2 | 1:3~1:6 | Negative | Online Inquiry |
KO21639 | SHLD2 Knockout cell line (A549) | Human | SHLD2 | 1:3~1:4 | Negative | Online Inquiry |
SHLD2 Gene Knockout Cell Lines are specially engineered cellular models in which the SHLD2 gene has been disrupted or entirely inactivated. This product serves as a pivotal tool for researchers examining the biological functions of the SHLD2 gene, particularly its role in DNA repair pathways and cellular response mechanisms to stressors such as ionizing radiation. By utilizing CRISPR/Cas9 technology, these knockout cell lines facilitate the targeted disruption of the SHLD2 gene, allowing for in-depth investigations into how the absence of this gene affects cell survival, proliferation, and genomic stability.
The primary function of the SHLD2 knockout lies in enabling scientists to dissect the molecular mechanisms underlying DNA damage response and repair processes. By studying these cell lines, researchers can elucidate how SHLD2 contributes to the regulation of DNA repair foci, potentially identifying key pathways that could be targeted in therapeutic interventions. This is especially relevant in the context of oncology, where understanding DNA repair pathways can inform treatment strategies to enhance the effectiveness of radiotherapy or chemotherapeutics.
One of the key advantages of SHLD2 Gene Knockout Cell Lines is their specificity and reliability for functional assays. Unlike alternative models, which may exhibit variable expression levels or may not accurately mimic the gene's in vivo environment, these knockout lines offer consistent and reproducible results, ensuring that researchers can draw valid conclusions about the SHLD2 gene’s functions.
For researchers and clinicians focusing on cancer biology and therapeutic resistance, the SHLD2 Gene Knockout Cell Lines provide an invaluable resource for advancing knowledge and contributing to the development of more effective treatments. Understanding the intricacies of DNA repair mechanisms may lead to identifying novel biomarkers for patient stratification and treatment response.
With a commitment to innovation and quality, our company specializes in the development and provision of advanced biological products that empower researchers and clinicians alike. Each product is backed by rigorous scientific validation and a focus on enhancing research efficacy, ensuring that our offerings meet the highest standards of excellence.
Please note that all services are for research use only. Not intended for any clinical use.
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