Gene: SGCE
Official Full Name: sarcoglycan epsilonprovided by HGNC
Gene Summary: This gene encodes the epsilon member of the sarcoglycan family. Sarcoglycans are transmembrane proteins that are components of the dystrophin-glycoprotein complex, which link the actin cytoskeleton to the extracellular matrix. Unlike other family members which are predominantly expressed in striated muscle, the epsilon sarcoglycan is more broadly expressed. Mutations in this gene are associated with myoclonus-dystonia syndrome. This gene is imprinted, with preferential expression from the paternal allele. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene associated with this gene is located on chromosome 2. [provided by RefSeq, Oct 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33741 | SGCE Knockout cell line (HeLa) | Human | SGCE | 1:3~1:6 | Negative | Online Inquiry |
KO33742 | SGCE Knockout cell line (HCT 116) | Human | SGCE | 1:2~1:4 | Negative | Online Inquiry |
KO33743 | SGCE Knockout cell line (HEK293) | Human | SGCE | 1:3~1:6 | Negative | Online Inquiry |
KO33744 | SGCE Knockout cell line (A549) | Human | SGCE | 1:3~1:4 | Negative | Online Inquiry |
SGCE Gene Knockout Cell Lines are specialized biological products designed to facilitate the detailed study of the SGCE gene's role in cellular function and disease. SGCE, or the epsilon-sarcoglycan gene, is important in the context of certain muscular dystrophies and neurobiological disorders. By employing CRISPR-Cas9 gene editing technology, our SGCE knockout cell lines eliminate the expression of this gene, thus providing researchers with a vital tool to investigate the consequences of SGCE deficiency at the molecular, cellular, and physiological levels.
These knockout cell lines function through the precise alteration of genomic DNA, resulting in the complete absence of the SGCE gene and its associated protein. Researchers can utilize these cell lines to explore the mechanisms underlying pathologies related to SGCE mutations, including their effects on cellular signaling, muscle integrity, and neural function. The ability to model these conditions in vitro offers unprecedented insights into disease mechanisms and potential therapeutic targets.
The scientific importance of SGCE gene knockout cell lines extends broadly into both research and clinical applications. As tools for drug discovery, they serve as essential platforms in preclinical studies to screen potential therapies for sarcoglycanopathies and related disorders. Additionally, these models can aid in understanding the genetic basis of various neurological conditions, thus contributing significantly to genetic and regenerative medicine.
What sets our SGCE Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability, backed by rigorous validation and characterization processes. Furthermore, they are produced under stringent quality controls, ensuring consistent performance and reproducibility across experiments. The use of our products translates into time and cost efficiency, fostering accelerated research timelines and enhancing the overall experimental workflow.
In summary, SGCE Gene Knockout Cell Lines are invaluable resources for researchers and clinicians keen on unraveling the complexities of diseases linked to the SGCE gene. Our company prides itself on a strong foundation in genetic engineering and cell line development, empowering researchers globally with cutting-edge tools that drive innovation and exploration in biological sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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