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SEMA6A Knockout Cell Lines

Gene: SEMA6A

Official Full Name: semaphorin 6Aprovided by HGNC

Gene Summary: Predicted to enable identical protein binding activity; signaling receptor binding activity; and transmembrane signaling receptor activity. Involved in cellular response to vascular endothelial growth factor stimulus; negative regulation of cell adhesion involved in sprouting angiogenesis; and negative regulation of signal transduction. Predicted to be located in axon and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05877 SEMA6A Knockout cell line (HCT 116) Human SEMA6A 1:2~1:4 Negative Online Inquiry
KO05878 SEMA6A Knockout cell line (HEK293) Human SEMA6A 1:3~1:6 Negative Online Inquiry

Background

SEMA6A Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the SEMA6A gene, which encodes for a semaphorin involved in various biological processes including neural development, axon guidance, and immune response regulation. By selectively knocking out this gene, researchers can study the functional consequences of its absence, revealing insights into SEMA6A's role in cellular signaling and disease etiology.

The primary mechanism of the SEMA6A gene knockout involves the use of CRISPR-Cas9 technology, which allows for precise editing of the genome. This method not only disrupts the SEMA6A gene but also facilitates the observation of downstream effects on cellular pathways, neurotransmitter release, and cell migration behavior. Consequently, these knockout cell lines serve as invaluable tools for elucidating the role of SEMA6A in pathophysiological conditions, such as neurodegenerative diseases and cancer.

The scientific significance of using SEMA6A Gene Knockout Cell Lines lies in their capacity to advance research regarding neural development and immune system dynamics. In clinical settings, these models can pave the way for novel therapeutic strategies targeting SEMA6A-related pathways, offering potential for developing interventions in diseases where SEMA6A is implicated.

These knockout cell lines stand out by providing a reliable, reproducible platform for both basic and applied research, significantly reducing the time and resources needed compared to traditional approaches such as overexpression or pharmacological inhibition. Importantly, the generation of these models aligns with our commitment to providing cutting-edge tools for researchers, ensuring they have access to high-quality, scientifically validated products.

Our company specializes in the development of genetically modified cell lines, drawing on extensive expertise in gene editing technologies. With a focus on facilitating advancements in scientific research and clinical applications, our SEMA6A Gene Knockout Cell Lines represent a crucial asset for researchers and clinicians alike, enabling them to unlock new dimensions in understanding and treating a range of serious conditions.

Please note that all services are for research use only. Not intended for any clinical use.

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