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RRAS2 Knockout Cell Lines

Gene: RRAS2

Official Full Name: RAS related 2provided by HGNC

Gene Summary: This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10481 RRAS2 Knockout cell line (HeLa) Human RRAS2 1:3~1:6 Negative Online Inquiry
KO10482 RRAS2 Knockout cell line (HCT 116) Human RRAS2 1:2~1:4 Negative Online Inquiry
KO10483 RRAS2 Knockout cell line (HEK293) Human RRAS2 1:3~1:6 Negative Online Inquiry
KO10484 RRAS2 Knockout cell line (A549) Human RRAS2 1:3~1:4 Negative Online Inquiry

Background

RRAS2 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the function and regulation of the RRAS2 gene, which plays a crucial role in intracellular signaling pathways influencing cell growth and differentiation. These cell lines are generated using CRISPR/Cas9 technology to effectively disrupt the native RRAS2 gene, allowing researchers to explore the downstream effects of its loss-of-function in various biological contexts.

The primary mechanism of these knockout cell lines revolves around the complete absence of the RRAS2 protein, which is known to modulate critical pathways such as the Ras-MAPK signaling pathway. By utilizing these cell lines, researchers can effectively assess the biological implications of RRAS2 deletion, unraveling its contribution to oncogenesis, cellular responses to growth factors, and tumor microenvironment interactions. This model is particularly valuable in cancer research, where aberrations in Ras family genes are frequently implicated.

In terms of scientific importance, RRAS2 Gene Knockout Cell Lines serve as a robust tool for elucidating the underlying mechanisms of disease processes. They can also facilitate the screening of potential therapeutic compounds, paving the way for novel treatment strategies against cancers harboring mutations in the Ras signaling pathway. Compared to traditional cell models which may retain functional RRAS2, these knockout lines present a more accurate representation of the gene's absence, offering clearer insights into its role.

One of the standout advantages of using RRAS2 Gene Knockout Cell Lines is their versatility in experimentation; they can be utilized in various assays such as proliferation, migration, and invasion studies. These lines are rigorously validated to ensure gene editing efficiency, providing researchers, and clinicians with confident results that are reproducible and reliable.

For researchers and clinical professionals seeking to deepen their understanding of RRAS2-related mechanisms, our RRAS2 Gene Knockout Cell Lines are invaluable. They offer a unique opportunity to construct a clearer picture of gene function in health and disease. Our company specializes in providing precisely engineered biological products, ensuring that researchers have access to high-quality tools necessary for impactful scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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