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RNF4 Knockout Cell Lines

Gene: RNF4

Official Full Name: ring finger protein 4provided by HGNC

Gene Summary: The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06911 RNF4 Knockout cell line (HeLa) Human RNF4 1:3~1:6 Negative Online Inquiry
KO06912 RNF4 Knockout cell line (HCT 116) Human RNF4 1:2~1:4 Negative Online Inquiry
KO06913 RNF4 Knockout cell line (HEK293) Human RNF4 1:3~1:6 Negative Online Inquiry
KO06914 RNF4 Knockout cell line (A549) Human RNF4 1:3~1:4 Negative Online Inquiry

Background

RNF4 Gene Knockout Cell Lines are specialized cellular models engineered for the study of the RNF4 gene, which plays a pivotal role in various biological processes, including protein degradation, transcriptional regulation, and cellular stress responses. These cell lines contain knockout mutations that allow researchers to effectively investigate the gene's functions by eliminating its expression, enabling a clearer understanding of RNF4's contributions to cell biology and disease mechanisms.

The key mechanism of these cell lines lies in their precision gene editing, utilizing advanced techniques such as CRISPR/Cas9. By specifically disrupting RNF4 expression, these cell lines provide a vital tool for studying gene function, protein-protein interactions, and the cellular implications of RNF4 deficiency. Investigators can explore the consequences of RNF4 loss on signaling pathways, substrate degradation, and cellular stress responses in ways that are not achievable with wild-type cell lines.

Scientifically, RNF4's importance is highlighted in research focused on cancer biology, neurodegenerative diseases, and cellular response to stress. RNF4 is implicated in the regulation of various oncogenic processes, making these knockout models invaluable for identifying potential therapeutic targets and understanding tumorigenesis. In clinical settings, insights derived from RNF4 knockout studies may inform the development of novel treatment strategies aimed at modulating RNF4-related pathways.

Compared to traditional cell lines, RNF4 Gene Knockout Cell Lines offer unparalleled specificity and reliability for investigating gene function. These models eliminate the variability often encountered with naturally occurring mutations, ensuring reproducible results and a more straightforward interpretation of data. Researchers will appreciate the ease of use and comprehensive support provided for experiments involving these knockout models.

For investigators focused on gene function characterization and the exploration of RNF4-related cellular mechanisms, our RNF4 Gene Knockout Cell Lines represent a significant enhancement to their research toolkit. Our company specializes in designing and providing high-quality biological products tailored to meet the evolving needs of researchers and clinicians alike, ensuring that you have access to the tools necessary for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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