Gene: RNF141
Official Full Name: ring finger protein 141provided by HGNC
Gene Summary: The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23255 | RNF141 Knockout cell line (HeLa) | Human | RNF141 | 1:3~1:6 | Negative | Online Inquiry |
KO23256 | RNF141 Knockout cell line (HCT 116) | Human | RNF141 | 1:2~1:4 | Negative | Online Inquiry |
KO23257 | RNF141 Knockout cell line (HEK293) | Human | RNF141 | 1:3~1:6 | Negative | Online Inquiry |
KO23258 | RNF141 Knockout cell line (A549) | Human | RNF141 | 1:3~1:4 | Negative | Online Inquiry |
RNF141 Gene Knockout Cell Lines are an innovative biological tool designed for advanced research in gene function and associated cellular pathways. These cell lines have been engineered to specifically disrupt the RNF141 gene, which encodes a RING-type E3 ubiquitin ligase involved in critical cellular processes, including protein degradation and cellular response to stress. By creating a knockout of this gene, researchers can examine the resultant phenotypic changes, providing insights into the gene's role in various biological contexts.
The primary mechanism of RNF141 Gene Knockout Cell Lines involves the complete abrogation of RNF141 expression, leading to altered proteostasis and subsequent effects on signal transduction pathways. This enables scientists to investigate the gene's influence on cellular processes such as apoptosis, cell cycle regulation, and immune responses. The ability to study these pathways is paramount in understanding diseases where RNF141 is implicated, such as certain cancers and neurodegenerative disorders.
The scientific importance of RNF141 knockout models extends to both fundamental research and clinical applications. They serve as critical tools for validating experimental hypotheses, evaluating drug responses, and discovering novel therapeutic targets. By elucidating the biological pathways affected by RNF141, researchers can develop better strategies for intervention in diseases linked to its dysfunction.
Compared to alternative gene knockout approaches, RNF141 Gene Knockout Cell Lines offer specificity and reliability, reducing the likelihood of off-target effects often encountered with traditional gene editing techniques. This specificity allows for precise investigations and reproducible results, which are essential for high-quality scientific research.
Researchers and clinicians seeking to deepen their understanding of RNF141-related mechanisms will find these cell lines invaluable. By providing a robust and versatile model, they facilitate groundbreaking discoveries, enhancing the potential for translating research findings into successful therapeutic strategies.
Our company is dedicated to advancing scientific truth through innovative biological products. With a profound expertise in cellular models, we strive to empower researchers and clinicians with high-quality tools that foster significant breakthroughs in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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