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RIMS4 Knockout Cell Lines

Gene: RIMS4

Official Full Name: regulating synaptic membrane exocytosis 4provided by HGNC

Gene Summary: Predicted to enable transmembrane transporter binding activity. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in several processes, including regulation of synapse organization; regulation of synaptic vesicle exocytosis; and synaptic vesicle exocytosis. Predicted to be located in synaptic membrane. Predicted to be active in glutamatergic synapse; presynaptic active zone cytoplasmic component; and presynaptic membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25558 RIMS4 Knockout cell line (HEK293) Human RIMS4 1:3~1:6 Negative Online Inquiry
KO25559 RIMS4 Knockout cell line (A549) Human RIMS4 1:3~1:4 Negative Online Inquiry

Background

RIMS4 Gene Knockout Cell Lines are genetically modified cell cultures that have been specifically designed to lack the expression of the RIMS4 gene, which is critical for neuronal function and synaptic transmission. These cell lines serve as valuable tools for researchers studying the molecular mechanisms underlying synaptic vesicle dynamics and neurotransmitter release, as well as their implications in neurodevelopmental and neurodegenerative disorders.

The key functionality of RIMS4 Gene Knockout Cell Lines lies in their ability to facilitate the investigation of RIMS4's role in neurotransmitter release mechanisms. By comparing the knockout cell lines to wild-type controls, researchers can elucidate the impact of RIMS4 absence on synaptic currents and overall neuronal communication. This targeted approach enables scientists to dissect the contributions of this gene in various physiological contexts and disease models, enhancing our understanding of synaptic pathology and potential treatment modalities.

The scientific importance of these cell lines extends to multiple applications, from basic research to the development of innovative therapies. In clinical settings, understanding the functions of RIMS4 can lead to novel interventions for conditions such as autism spectrum disorders and other cognitive dysfunctions linked to synaptic malfunctions. By deploying these knockout cell lines, researchers can more effectively assess the efficacy of pharmacological compounds aimed at restoring synaptic function.

RIMS4 Gene Knockout Cell Lines offer several distinct advantages over traditional knockout methodologies, including consistent cellular background, enhanced reproducibility, and the ability to be adapted for high-throughput screening assays. This allows for more efficient data acquisition and analysis while minimizing experimental variability.

For researchers and clinicians, the value of RIMS4 Gene Knockout Cell Lines lies in their potential to accelerate discoveries related to synaptic biology and neuropharmacology. Our company is committed to providing high-quality biological products that empower the scientific community, backed by years of expertise in gene editing technologies and cell line development. We work closely with researchers to ensure that our offerings meet the rigorous demands of modern biological research and contribute significantly to advancing our understanding of health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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